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Outbreak of Acinetobacter baumannii producing OXA-66 in a Spanish hospital: epidemiology and study of patient movements

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dc.contributor.author Culebras, Esther spa
dc.contributor.author González-Romo, Fernando spa
dc.contributor.author Head, Jacqueline spa
dc.contributor.author Gómez, María spa
dc.contributor.author Morales Kucharski, María Gracia spa
dc.contributor.author Picazo, Juan José spa
dc.date.accessioned 2013-11-27T17:26:47Z
dc.date.available 2013-11-27T17:26:47Z
dc.date.issued 2010 spa
dc.identifier.citation Culebras, E., González-Romo, F., Head, J., Gómez, M., Morales, G., & Picazo, J. J. (2010). Outbreak of Acinetobacter baumannii producing OXA-66 in a Spanish hospital: epidemiology and study of patient movements. Microbial Drug Resistance, 16(4), 309-315. spa
dc.identifier.uri http://hdl.handle.net/11268/1040
dc.description.abstract We describe an outbreak of multidrug-resistant Acinetobacter baumannii producing OXA-66 carbapenemase and resistant to imipenem. We analyze the relationship between the spread of this strain and patient movements within the hospital. Thirty-one isolates of A. baumannii recovered from December 21, 2006, to February 18, 2007, were studied. Enterobacterial repetitive intergenic consensus PCR and randomly amplified polymorphic DNA genotyping methods were used to define clusters of clonally related isolates. Pulsed-field gel electrophoresis was used to confirm the results and to check the maintenance of the epidemic strain over the following year. Antibiotic susceptibility testing was performed by microdilution and E-test. The isolates were screened by PCR analysis with primers specific for carbapenemase genes. With the exception of colistin (0%) there were no antibiotics with good activity against these isolates. The epidemiology study revealed that the same strain was responsible for all the infections. This strain appeared to carry the bla(OXA-66) gene. ISAba1 was present upstream the oxacillinase gene. The clone responsible for the outbreak is still present in hospital. spa
dc.language.iso eng spa
dc.title Outbreak of Acinetobacter baumannii producing OXA-66 in a Spanish hospital: epidemiology and study of patient movements spa
dc.type article spa
dc.description.impact 1.936 JCR (2010) Q3, 43/58 Infectious diseases, 67/107 Microbiology, 143/252 Pharmacology & pharmacy spa
dc.identifier.doi 10.1089/mdr.2009.0113 spa
dc.rights.accessRights closedAccess en
dc.subject.unesco Enfermedad transmisible spa


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