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Microarchitectural changes during development of the cerebellar cortex

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dc.contributor.author Mecha, Míriam spa
dc.contributor.author Peña-Melián, Ángel L. spa
dc.contributor.author Blanco Fernández de Valderrama, María José spa
dc.date.accessioned 2013-11-27T17:25:40Z
dc.date.available 2013-11-27T17:25:40Z
dc.date.issued 2010 spa
dc.identifier.citation Mecha, M., Peña-Melián, A. L., & Blanco-Fernández, M. J. (2010). Microarchitectural changes during development of the cerebellar cortex. International Journal of Developmental Biology, 54(4), 691-698. spa
dc.identifier.issn 16963547 spa
dc.identifier.uri http://hdl.handle.net/11268/123
dc.description.abstract The cerebellum is a highly conserved structure in the Central Nervous System (CNS) of vertebrates, and is involved in the coordination of voluntary motor behaviour. Supporting this function, the cerebellar cortex presents a layered structure which requires a precise spatial and temporal coordination of proliferation, migration and differentiation events. One of the characteristics of the developing cortex is the formation of the external granule cell layer (EGL) in the outermost part. The EGL is a highly proliferative transient layer which disappears when cells migrate inwards to form the inner granule cell layer. The balance between proliferation and migration leads to changes in EGL thickness, and might be related to "indentations" observed in the surface of the developing chick cerebellum. We have extended the observation of this feature to quail and mouse, supporting the idea that this phenomenon forms part of the mechanisms of cerebellar morphogenesis. Different factors involved in both mitotic activity and migration were analyzed in this study. Our results indicate that proliferation, more than formation of raphes for cell migration, is involved in the formation of indentations in the EGL. In addition, we show that vessels penetrating from the pial surface divide the EGL into regular regions at the time of the appearance of bulges and furrows. We conclude that indentations are the result of a coincidence in time of both the increase in thickness of the EGL and the establishment of the embryonic vascular pattern, which confers a characteristic transitory morphology to the surface of folia. spa
dc.language.iso eng spa
dc.subject.other Cerebellar Cortex/*Cytology spa
dc.subject.other Cerebellar Cortex/*Growth & Development spa
dc.subject.other Cerebellum/*Cytology spa
dc.subject.other Cerebellum/*Growth & Development spa
dc.subject.other Neovascularization, Physiologic/*Genetics spa
dc.subject.other Animals spa
dc.subject.other Cell Differentiation/Genetics spa
dc.subject.other Cell Movement/Genetics spa
dc.subject.other Cell Movement/Physiology spa
dc.subject.other Cerebellar Cortex/Metabolism spa
dc.subject.other Cerebellum/Embryology spa
dc.subject.other Cytoplasmic Granules/Genetics spa
dc.subject.other Cytoplasmic Granules/Metabolism spa
dc.subject.other Mice spa
dc.subject.other Mice, Inbred C57bl spa
dc.subject.other Neurons/Cytology spa
dc.subject.other Neurons/Metabolism spa
dc.title Microarchitectural changes during development of the cerebellar cortex spa
dc.type article spa
dc.description.impact 2.856 JCR (2010) Q2, 18/38 Developmental biology spa
dc.identifier.doi 10.1387/ijdb.082670mm spa
dc.rights.accessRights closedAccess en


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