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Second trimester amniotic fluid adiponectin level is affected by maternal tobacco exposure, insulin, and PAPP-A level

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dc.contributor.author León-Luis, J. de spa
dc.contributor.author Perez, R. spa
dc.contributor.author Pintado Recarte, P. spa
dc.contributor.author Avellaneda Fernández, Alfredo spa
dc.contributor.author Romero Román, C. spa
dc.contributor.author Antolín Alvarado, E. spa
dc.contributor.author Ortiz-Quintana, L. spa
dc.contributor.author Izquierdo Martínez, Maravillas spa
dc.date.accessioned 2013-11-27T17:26:48Z
dc.date.available 2013-11-27T17:26:48Z
dc.date.issued 2012 spa
dc.identifier.citation León-Luis, J., Pérez, R., Pintado-Recarte, P., Avellaneda-Fernández, A., Romero-Román, C., Antolín-Alvarado, E., ..., & Izquierdo-Martínez, M. (2012). Second trimester amniotic fluid adiponectin level is affected by maternal tobacco exposure, insulin, and PAPP-A level. European Journal of Obstetrics & Gynecology and Reproductive Biology, 165(2), 189-193. spa
dc.identifier.issn 03012115 spa
dc.identifier.uri http://hdl.handle.net/11268/1061
dc.description.abstract OBJECTIVES: Adiponectin is an adipocyte-derived plasma protein with insulin-sensitizing and antiatherosclerotic properties. The objectives of the present study were to determine the amniotic fluid (AF) concentration of adiponectin during the second trimester of pregnancy and to demonstrate its association with maternal and fetal variables and AF concentrations of insulin, leptin, and pregnancy-associated-plasma-protein A (PAPP-A). STUDY DESIGN: We performed a cross-sectional study of 222 pregnant women who underwent amniocentesis at 15-18 weeks for genetic reasons. No malformation or chromosomal disorder was found in the newborn after birth. AF adiponectin, leptin, PAPP-A, and insulin concentrations were measured using commercially available assays. All maternal, fetal, and biochemical variables were studied using univariate and multivariate linear regression analysis to determine their association with the AF concentration of adiponectin. RESULTS: Adiponectin concentration was negatively correlated with maternal smoking status (β=-5.208; p<0.001) and positively correlated with levels of insulin (β=0.621; p=0.002) and PAPP-A (β=40.150; p<0.001). Non-significant correlations were found between adiponectin concentration and maternal age, maternal body mass index, gestational age at amniocentesis, fetal gender, and AF level of leptin. CONCLUSION: These findings suggest that the fetus and its membrane adipocytokines, in relationship with maternal and other fetal variables, play a dynamic role in the regulation of energy and oxidative stress homeostasis due to its insulin-sensitizing and antiatherosclerotic effects. The association of these molecules with maternal tobacco consumption during pregnancy could have perinatal implications. spa
dc.language.iso eng spa
dc.title Second trimester amniotic fluid adiponectin level is affected by maternal tobacco exposure, insulin, and PAPP-A level spa
dc.type article spa
dc.description.impact 1.843 JCR (2012) Q2, 34/78 Obstetrics & gynecology; Q4, 22/28 Reproductive biology spa
dc.identifier.doi 10.1016/j.ejogrb.2012.07.031 spa
dc.rights.accessRights closedAccess en
dc.subject.unesco Ciencias médicas spa
dc.peerreviewed Si spa


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