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The champions' mitochondria: is it genetically determined? A review on mitochondrial DNA and elite athletic performance

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dc.contributor.author Eynon, Nir spa
dc.contributor.author Morán, María spa
dc.contributor.author Birk, Ruth spa
dc.contributor.author Lucía Mulas, Alejandro spa
dc.date.accessioned 2013-11-27T17:26:49Z
dc.date.available 2013-11-27T17:26:49Z
dc.date.issued 2011 spa
dc.identifier.citation Eynon, N., Morán, M., Birk, R., & Lucía-Mulas, A. (2011). The champions' mitochondria: is it genetically determined? A review on mitochondrial DNA and elite athletic performance. Physiological Genomics, 43(13), 789-798. spa
dc.identifier.issn 15312267 spa
dc.identifier.uri http://hdl.handle.net/11268/1066
dc.description.abstract Aerobic ATP generation by the mitochondrial respiratory oxidative phosphorylation system (OXPHOS) is a vital metabolic process for endurance exercise. Notably, mitochondrial DNA (mtDNA) codifies 13 of the 83 polypeptides implied in the respiratory chain. As such, there is a strong rationale for identifying an association between mtDNA variants and "aerobic" (endurance) exercise phenotypes. The aim of this review is to summarize current knowledge on the association between mtDNA, nuclear genes involved in mitochondriogenesis, and elite endurance athletic status. Several studies in nonathletic people have demonstrated an association between certain mtDNA lineages and aerobic performance, characterized by maximal oxygen uptake (VO2max). Whether mtDNA haplogroups are also associated with the status of being an elite endurance athlete is more controversial, with differences between studies arising from the different ethnic backgrounds of the athletic cohorts (Caucasian of mixed geographic origin, Asiatic, or East African). spa
dc.language.iso eng spa
dc.title The champions' mitochondria: is it genetically determined? A review on mitochondrial DNA and elite athletic performance spa
dc.type article spa
dc.description.impact 2.735 JCR (2011) Q2, 28/79 Physiology, 72/158 Genetics & heredity; Q3, 108/181 Cell biology spa
dc.identifier.doi 10.1152/physiolgenomics.00029.2011 spa
dc.rights.accessRights openAccess en
dc.subject.unesco Medicina deportiva spa
dc.subject.unesco Genética humana spa
dc.subject.unesco Atleta spa
dc.description.filiation UEM spa
dc.peerreviewed Si spa


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