Elevated linezolid resistance in clinical cfr-positive Staphylococcus aureus isolates is associated with co-occurring mutations in ribosomal protein L3

Locke, Jeffrey B.; Morales Kucharski, María Gracia; Hilgers, Mark; Kedar, G. C.; Rahawi, Shahad; Picazo, Juan José; Shaw, Karen Joy; Stein, Jeffrey L.

doi:10.1128/AAC.00714-10

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Elevated linezolid resistance in clinical cfr-positive Staphylococcus aureus isolates is associated with co-occurring mutations in ribosomal protein L3

Locke, Jeffrey B.; Morales Kucharski, María Gracia; Hilgers, Mark; Kedar, G. C.; Rahawi, Shahad; Picazo, Juan José; Shaw, Karen Joy; Stein, Jeffrey L.

Use this identifier to cite or link to this item: http://hdl.handle.net/11268/1075

Date: 2010

UNESCO Subject: Microbiología
UNESCO Subject: Bacteriología

Type: article

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Abstract:

Resistance to linezolid (LZD) occurs through mutations in 23S rRNA and ribosomal proteins L3 and L4 or through methylation of 23S rRNA by Cfr. Here we report novel L3 mutations, ΔSer145/His146Tyr and ΔMet169-Gly174, co-occurring with <I>cfr</I> in LZD-resistant <I>Staphylococcus aureus</I> isolates recovered from a hospital outbreak in Madrid, Spain. LZD MIC values (16, 32, or 64 μg/ml) correlated with the presence and severity of the L3 mutation. All isolates had TR-700 (torezolid) MIC values of ≤2 μg/ml.

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