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Excessive skeletal muscle recruitment during strenuous exercise in McArdle patients

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dc.contributor.author Rae, Dale E. spa
dc.contributor.author Noakes, Timothy D. spa
dc.contributor.author San Juan, Alejandro F. spa
dc.contributor.author Pérez Ruiz, Margarita spa
dc.contributor.author Nogales-Gadea, Gisela spa
dc.contributor.author Ruiz, Jonatan R. spa
dc.contributor.author Morán, María spa
dc.contributor.author Martín, Miguel Ángel spa
dc.contributor.author Andreu, Antoni L. spa
dc.contributor.author Arenas, Joaquín spa
dc.contributor.author Lucía Mulas, Alejandro spa
dc.date.accessioned 2013-11-27T17:26:51Z
dc.date.available 2013-11-27T17:26:51Z
dc.date.issued 2010 spa
dc.identifier.citation Rae, D. E., Noakes, T. D., San-Juan, A. F., Pérez-Ruiz, M., Nogales-Gadea, G., Ruiz, J. R., ..., & Lucía-Mulas, A. (2010). Excessive skeletal muscle recruitment during strenuous exercise in McArdle patients. European Journal of Applied Physiology, 110(5), 1047-1055. spa
dc.identifier.issn 14396327 spa
dc.identifier.uri http://hdl.handle.net/11268/1096
dc.description.abstract We compared the cardiorespiratory response and muscle recruitment [as determined by electromyography (EMG)] of 37 McArdle patients [19 males, 37.4 ± 2.8 years, body mass index (BMI): 25.1 ± 4.7 kg m(-2)] and 33 healthy controls (18 males, 36.4 ± 10.0 years, BMI: 25.7 ± 3.8 kg m(-2)) during cycle-ergometer exercise (an incremental test to exhaustion and a 12-min submaximal constant workload test). We obtained cardiorespiratory [oxygen uptake and heart rate (HR)] and EMG data (rectus femoris and vastus lateralis muscles). During the incremental test, the patients exhibited the expected hyperkinetic cardiovascular response shown by a marked increase in the slope of the HR:Power relationship (p < 0.001). Throughout the incremental test and at the point of fatigue, the patients produced significantly less power than the controls (peak power output: 67 ± 21 vs. 214 ± 56 watts respectively, p < 0.001), yet they demonstrated significantly higher levels of muscle activity for a given absolute power. During the constant workload test, patients displayed higher levels of EMG activity than the controls during the second half of the test, despite a lower power production (34 ± 13 vs. 94 ± 29 watts respectively, p < 0.001). In conclusion, since the McArdle patients required more motor unit recruitment for a given power output, our data suggest that the state of contractility of their muscles is reduced compared with healthy people. Excessive muscle recruitment for a given load could be one of the mechanisms explaining the exercise intolerance of these patients. spa
dc.language.iso eng spa
dc.title Excessive skeletal muscle recruitment during strenuous exercise in McArdle patients spa
dc.type article spa
dc.description.impact 2.214 JCR (2010) Q2, 23/80 Sport sciences; Q3, 41/78 Physiology spa
dc.identifier.doi 10.1007/s00421-010-1585-5 spa
dc.rights.accessRights openAccess en
dc.subject.unesco Enfermedad nutricional spa
dc.subject.unesco Deporte spa
dc.subject.unesco Tratamiento médico spa
dc.description.filiation UEM spa
dc.peerreviewed Si spa


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