dc.contributor.author |
Rae, Dale E. |
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dc.contributor.author |
Noakes, Timothy D. |
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dc.contributor.author |
San Juan, Alejandro F. |
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dc.contributor.author |
Pérez Ruiz, Margarita
|
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dc.contributor.author |
Nogales-Gadea, Gisela |
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dc.contributor.author |
Ruiz, Jonatan R. |
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dc.contributor.author |
Morán, María |
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dc.contributor.author |
Martín, Miguel Ángel |
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dc.contributor.author |
Andreu, Antoni L. |
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dc.contributor.author |
Arenas, Joaquín |
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dc.contributor.author |
Lucía Mulas, Alejandro
|
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dc.date.accessioned |
2013-11-27T17:26:51Z |
|
dc.date.available |
2013-11-27T17:26:51Z |
|
dc.date.issued |
2010 |
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dc.identifier.citation |
Rae, D. E., Noakes, T. D., San-Juan, A. F., Pérez-Ruiz, M., Nogales-Gadea, G., Ruiz, J. R., ..., & Lucía-Mulas, A. (2010). Excessive skeletal muscle recruitment during strenuous exercise in McArdle patients. European Journal of Applied Physiology, 110(5), 1047-1055. |
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dc.identifier.issn |
14396327 |
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dc.identifier.uri |
http://hdl.handle.net/11268/1096 |
|
dc.description.abstract |
We compared the cardiorespiratory response and muscle recruitment [as determined by electromyography (EMG)] of 37 McArdle patients [19 males, 37.4 ± 2.8 years, body mass index (BMI): 25.1 ± 4.7 kg m(-2)] and 33 healthy controls (18 males, 36.4 ± 10.0 years, BMI: 25.7 ± 3.8 kg m(-2)) during cycle-ergometer exercise (an incremental test to exhaustion and a 12-min submaximal constant workload test). We obtained cardiorespiratory [oxygen uptake and heart rate (HR)] and EMG data (rectus femoris and vastus lateralis muscles). During the incremental test, the patients exhibited the expected hyperkinetic cardiovascular response shown by a marked increase in the slope of the HR:Power relationship (p < 0.001). Throughout the incremental test and at the point of fatigue, the patients produced significantly less power than the controls (peak power output: 67 ± 21 vs. 214 ± 56 watts respectively, p < 0.001), yet they demonstrated significantly higher levels of muscle activity for a given absolute power. During the constant workload test, patients displayed higher levels of EMG activity than the controls during the second half of the test, despite a lower power production (34 ± 13 vs. 94 ± 29 watts respectively, p < 0.001). In conclusion, since the McArdle patients required more motor unit recruitment for a given power output, our data suggest that the state of contractility of their muscles is reduced compared with healthy people. Excessive muscle recruitment for a given load could be one of the mechanisms explaining the exercise intolerance of these patients. |
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dc.language.iso |
eng |
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dc.title |
Excessive skeletal muscle recruitment during strenuous exercise in McArdle patients |
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dc.type |
article |
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dc.description.impact |
2.214 JCR (2010) Q2, 23/80 Sport sciences; Q3, 41/78 Physiology |
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dc.identifier.doi |
10.1007/s00421-010-1585-5 |
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dc.rights.accessRights |
closedAccess |
en |
dc.subject.unesco |
Enfermedad nutricional |
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dc.subject.unesco |
Deporte |
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dc.subject.unesco |
Tratamiento médico |
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dc.description.filiation |
UEM |
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dc.peerreviewed |
Si |
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