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Does the ACE I/D polymorphism, alone or in combination with the ACTN3 R577X polymorphism, influence muscle power phenotypes in young, non-athletic adults?

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dc.contributor.author Rodríguez Romo, Gabriel spa
dc.contributor.author Ruiz, Jonatan R. spa
dc.contributor.author Santiago Dorrego, Catalina spa
dc.contributor.author Fiuza Luces, María del Carmen spa
dc.contributor.author González-Freire, Marta spa
dc.contributor.author Gómez Gallego, Félix spa
dc.contributor.author Morán, María spa
dc.contributor.author Lucía Mulas, Alejandro spa
dc.date.accessioned 2013-11-27T17:26:51Z
dc.date.available 2013-11-27T17:26:51Z
dc.date.issued 2010 spa
dc.identifier.citation Rodríguez-Romo, G., Ruiz, J. R., Santiago-Dorrego, C., Fiuza-Luces, C., González-Freire, M., Gómez-Gallego, F., ..., & Lucía-Mulas, A. (2010). Does the ACE I/D polymorphism, alone or in combination with the ACTN3 R577X polymorphism, influence muscle power phenotypes in young, non-athletic adults? European Journal of Applied Physiology, 110(6), 1099-1106. spa
dc.identifier.issn 14396327 spa
dc.identifier.uri http://hdl.handle.net/11268/1112
dc.description.abstract We investigated the association of the angiotensin converting enzyme gene (ACE) insertion/deletion (I/D) polymorphism, alone or in combination with the α-actinin-3 gene (ACTN3) R577X polymorphism, with jumping (vertical squat and counter-movement jump tests) and sprint ability (30 m dash) in non-athletic, healthy young adults [N = 281 (214 male), mean (SD) age 21 (2) years]. We did not observe any effect of the ACE I/D polymorphism on study phenotypes. We repeated the analyses separately in men and women and the results did not materially change. Likewise, the mean estimates of the study phenotypes were similar in subjects with the genotype combinations ACE II + ID and ACTN3 XX or ACE DD and ACTN3 RR + RX. We found no association between the ACE DD and ACTN3 RR + RX genotype combination and performance (≥90th of the sex-specific percentile). In summary, though the ACE I/D polymorphism is a strong candidate to modulate some exercise-related phenotypes or athletic performance status, this polymorphism, alone or in combination with the ACTN3 R577X polymorphism, does not seem to exert a major influence in the muscle 'explosive' power of young healthy adults, as assessed during multi-joint exercise tests. spa
dc.language.iso eng spa
dc.title Does the ACE I/D polymorphism, alone or in combination with the ACTN3 R577X polymorphism, influence muscle power phenotypes in young, non-athletic adults? spa
dc.type article spa
dc.description.impact 2.214 JCR (2010) Q2, 23/80 Sport sciences; Q3, 41/78 Physiology spa
dc.identifier.doi 10.1007/s00421-010-1608-2 spa
dc.rights.accessRights closedAccess en
dc.subject.unesco Genética humana spa
dc.subject.unesco Fisiología humana spa
dc.description.filiation UEM spa
dc.peerreviewed Si spa


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