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Morphological evidence of muscular connections between contiguous pulmonary venous orifices: Relevance of the interpulmonary isthmus for catheter ablation in atrial fibrillation

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dc.contributor.author Cabrera Rodríguez, José Ángel spa
dc.contributor.author Ho, Siew Yen spa
dc.contributor.author Climent, Vicente spa
dc.contributor.author Fuertes Suárez, Beatriz spa
dc.contributor.author Murillo Haba, Margarita spa
dc.contributor.author Sánchez-Quintana, Damián spa
dc.date.accessioned 2013-11-27T17:25:44Z
dc.date.available 2013-11-27T17:25:44Z
dc.date.issued 2009 spa
dc.identifier.citation Cabrera-Rodríguez, J. A., Ho, S. Y., Climent, V., Fuertes-Suárez, B., Murillo-Haba, M., & Sánchez-Quintana, D. (2009). Morphological evidence of muscular connections between contiguous pulmonary venous orifices: relevance of the interpulmonary isthmus for catheter ablation in atrial fibrillation. HeartRhythm, 6(8), 1192-1198. spa
dc.identifier.issn 15475271 spa
dc.identifier.uri http://hdl.handle.net/11268/153
dc.description.abstract BACKGROUND Electrophysiological studies in patients with atrial fibrillation demonstrated the presence of etectrical conduction between superior and inferior left pulmonary veins (PVs) that makes electrical disconnection of individual PVs difficult. Anatomically, the prevalence, sizes, and locations of the interpulmonary connections have not been investigated systematically. METHODS We retrieved 112 PVs from 28 patients who died from noncardiac causes (43 +/- 13 years, 17 mates). Dissections of subepicardial myocardial strands at the venoatrial junctions were made in 10 hearts, and histological sections were made in the remaining 18 hearts. RESULTS We found histological variations in the muscular width of the interpulmonary isthmus between ipsilateral left and right PVs (2.7 +/- 0.5 mm vs 1.7 +/- 0.5 mm; P < .05). Histologic sections of 15 hearts revealed myocardial strands 0.2-3.5 mm thick crossing obliquely at the Left isthmus in 53%, at the right isthmus in 33%, and at both isthmuses in 14% of hearts to connect with the myocardial sleeves of adjacent veins. In 40% of hearts there were additional direct bridges connecting the anterior or posterior watts of the veins. The crossing myocardial strands were at the epicardial (27% of hearts), subendocardial (53% of hearts), and both (20%) aspects of the PV wall. The mean distance between the endocardium of the interpulmonary isthmus to the muscular connections was 2.5 +/- 0.5 mm in the Left-sided PVs and 1.5 +/- 0.5 mm in the right-sided PVs. CONCLUSIONS Crossing myocardial strands and bridges at the interpulmonary isthmus may be the anatomical substrate for electrical connection between superior and inferior PVs and may have implications for local PV isolation in patients with atrial fibrillation. spa
dc.language.iso eng spa
dc.subject.other Atrial Fibrillation spa
dc.subject.other Atrium spa
dc.subject.other Pulmonary Veins spa
dc.subject.other Radiofrequency Ablation spa
dc.subject.other Vein Isolation spa
dc.subject.other Ectopic Beats spa
dc.subject.other Electrical spa
dc.subject.other Connections spa
dc.subject.other Ostial Ablation spa
dc.subject.other Conduction spa
dc.subject.other Disconnection spa
dc.subject.other Architecture spa
dc.subject.other Recurrence spa
dc.subject.other Initiation spa
dc.subject.other Cardiovascular System & Cardiology spa
dc.title Morphological evidence of muscular connections between contiguous pulmonary venous orifices: Relevance of the interpulmonary isthmus for catheter ablation in atrial fibrillation spa
dc.type article spa
dc.description.impact 4.559 JCR (2009) Q1, 12/95 Cardiac & cardiovascular systems spa
dc.identifier.doi 10.1016/j.hrthm.2009.04.016 spa
dc.rights.accessRights closedAccess en
dc.subject.unesco Enfermedad spa
dc.subject.unesco Fisiología humana spa
dc.peerreviewed Si spa


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