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Exercise benefits in chronic graft versus host disease: A Murine model study

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dc.contributor.author Fiuza Luces, María del Carmen spa
dc.contributor.author Soares-Miranda, Luisa spa
dc.contributor.author González-Murillo, África spa
dc.contributor.author Palacio, J. M. spa
dc.contributor.author Colmenero, Isabel spa
dc.contributor.author Casco Claro, Fernando spa
dc.contributor.author Melén, Gustavo spa
dc.contributor.author Delmiro, Aitor spa
dc.contributor.author Morán, María spa
dc.contributor.author Ramírez, Manuel spa
dc.contributor.author Lucía Mulas, Alejandro spa
dc.date.accessioned 2014-03-18T10:07:05Z
dc.date.available 2014-03-18T10:07:05Z
dc.date.issued 2013 spa
dc.identifier.citation Fiuza-Luces, M. C., Soares-Miranda, L., González-Murillo, A., Palacio, J. M., Colmenero, I., Casco, F., ..., & Lucía-Mulas, A. (2013). Exercise benefits in chronic graft versus host disease: a murine model study. Medicine and Science in Sports and Exercise, 45, 1703-1711. spa
dc.identifier.uri http://hdl.handle.net/11268/1956
dc.description.abstract Chronic graft versus host disease (cGVHD) is a life-threatening complication of allogeneic hematopoietic stem cell transplantation that generates considerable morbidity and compromises the physical capacity of patients. We determined the effects of an exercise training program performed after allogeneic hematopoietic stem cell transplantation on clinical and biological variables in a minor histocompatibility antigen-driven murine model of cGVHD treated with cyclosporine A. Recipient BALB/C female mice (age 8 wk) received bone marrow cells and splenocytes from donor B10.D2 male mice and were randomly assigned to an exercise (n = 11) or control group (n = 12). For approximately 11 wk after transplant, the exercise group completed a moderate-intensity treadmill program. Variables assessed were clinical severity scores, survival, physical fitness, cytokine profile, immune cell reconstitution, molecular markers of muscle exercise adaptations, and histological scores in affected tissues. Exercise training increased survival (P = 0.011), diminished total clinical severity scores (P = 0.002), improved physical fitness (P = 0.030), and reduced blood IL-4 and tumor necrosis factor α levels (P = 0.03), while increasing circulating B220 (P = 0.008) and CD4 lymphocytes (P = 0.043). A moderate-intensity exercise program that mimics widely accepted public health recommendations for physical activity in human adults was well tolerated and positive effects on survival as well as on clinical and biological indicators of cGVHD. spa
dc.language.iso eng spa
dc.title Exercise benefits in chronic graft versus host disease: A Murine model study spa
dc.type article spa
dc.description.impact 4.459 JCR (2013) Q1, 5/81 Sport sciences spa
dc.identifier.doi 10.1249/MSS.0b013e31828fa004 spa
dc.rights.accessRights openAccess en
dc.subject.unesco Enfermedad spa
dc.subject.unesco Deporte spa
dc.description.filiation UEM spa
dc.peerreviewed Si spa


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