The 'McArdle paradox': Exercise is a good advice for the exercise intolerant

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dc.contributor.author Lucía Mulas, Alejandro spa
dc.contributor.author Quinlivan, Ros spa
dc.contributor.author Wakelin, Andrew spa
dc.contributor.author Martín, Miguel Ángel spa
dc.contributor.author Andreu, Antoni L. spa
dc.date.accessioned 2014-03-18T10:07:05Z
dc.date.available 2014-03-18T10:07:05Z
dc.date.issued 2013 spa
dc.identifier.citation Lucía-Mulas, A., Quinlivan, R., Wakelin, A., Martín, M. A., & Andreu, A. L. (2013). The ‘McArdle paradox’: exercise is a good advice for the exercise intolerant. British Journal of Sports Medicine, 47(12), 728-729. spa
dc.identifier.uri http://hdl.handle.net/11268/1959
dc.description.abstract McArdle disease (glycogen storage disease type V, OMIM database number 232600) may provide the ultimate model of exercise intolerance in humans, and thus is of great interest in the sports medicine setting. The condition is an autosomal recessive disorder of muscle glycogen metabolism originally described in 1951 by Brian McArdle.1 Patients have pathogenic mutations in both alleles of the PYGM gene, which encodes myophosphorylase, the skeletal muscle isoform of glycogen phosphorylase.2 As a result, myophosphorylase activity is totally absent. Because this enzyme initiates the breakdown of muscle glycogen leading to liberation of glucose-1-phosphate, patients are unable to obtain energy from their muscle glycogen stores. Hence this disease is arguably the paradigm of exercise intolerance in humans.2 Exercise is the trigger for symptom occurrence in McArdle patients; as such, they tend to be averse to exercise and have often been advised by clinicians to refrain from exercise. spa
dc.language.iso eng spa
dc.title The 'McArdle paradox': Exercise is a good advice for the exercise intolerant spa
dc.type article spa
dc.description.impact 4.171 JCR (2013) Q1, 6/81 Sport sciences spa
dc.identifier.doi 10.1136/bjsports-2012-091130 spa
dc.rights.accessRights openAccess en
dc.subject.unesco Enfermedad nutricional spa
dc.subject.unesco Deporte spa
dc.description.filiation UEM spa
dc.peerreviewed Si spa

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