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Epileptic seizures in diffuse low-grade gliomas in adults

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dc.contributor.author Pallud, Johan spa
dc.contributor.author Audureau, Etienne spa
dc.contributor.author Blonski, Marie spa
dc.contributor.author Sanai, Nader spa
dc.contributor.author Bauchet, Luc spa
dc.contributor.author Fontaine, Denys spa
dc.contributor.author Mandonnet, Emmanuel spa
dc.contributor.author Dezamis, Edouard spa
dc.contributor.author Psimaras, Dimitri spa
dc.contributor.author Guyotat, Jacques spa
dc.contributor.author Peruzzi, Philippe spa
dc.contributor.author Page, Philippe spa
dc.contributor.author Gal Iglesias, Beatriz spa
dc.contributor.author Párraga, Eduardo spa
dc.contributor.author Baron, Marie-Hélèn spa
dc.contributor.author Vlaicu, Michaela spa
dc.contributor.author Guillevin, Rémy spa
dc.contributor.author Devaux, Bertrand spa
dc.contributor.author Duffau, Hugues spa
dc.contributor.author Taillandier, Luc spa
dc.contributor.author Capelle, Laurent spa
dc.contributor.author Huberfeld, Gilles spa
dc.date.accessioned 2014-03-18T10:09:19Z
dc.date.available 2014-03-18T10:09:19Z
dc.date.issued 2014 spa
dc.identifier.citation Pallud, J., Audureau, E., Blonski, M., Sanai, N., Bauchet, L., Fontaine, D., ..., & Huberfeld, G. (2014). Epileptic seizures in diffuse low-grade gliomas in adults. Brain, 137(2), 449-462. spa
dc.identifier.issn 14602156 spa
dc.identifier.issn 00068950 spa
dc.identifier.uri http://hdl.handle.net/11268/2193
dc.description.abstract Diffuse low-grade gliomas are highly epileptogenic brain tumours. We aimed to explore the natural course of epileptic seizures, their predictors and the prognostic significance of their occurrence in adult patients harbouring a diffuse low-grade glioma. An observational retrospective multicentre study examined 1509 patients with diffuse low-grade gliomas to identify mutual interactions between tumour characteristics, tumour course and epileptic seizures. At diagnosis, 89.9% of patients had epileptic seizures. Male gender (P = 0.003) and tumour location within functional areas (P = 0.001) were independent predictors of a history of epileptic seizures at diagnosis. Tumour volume, growth velocity, cortical location, histopathological subtype or molecular markers did not significantly affect epileptic seizure occurrence probability. Prolonged history of epileptic seizures (P < 0.001), insular location (P = 0.003) and tumour location close to functional areas (P = 0.038) were independent predictors of uncontrolled epileptic seizures at diagnosis. Occurrence of epileptic seizures (P < 0.001), parietal (P = 0.029) and insular (P = 0.002) locations were independent predictors of uncontrolled epileptic seizures after oncological treatment. Patient age (P < 0.001), subtotal (P = 0.007) and total (P < 0.001) resections were independent predictors of total epileptic seizure control after oncological treatment. History of epileptic seizures at diagnosis and total surgical resection were independently associated with increased malignant progression-free (P < 0.001 and P < 0.001) and overall (P < 0.001 and P = 0.016) survivals. Epileptic seizures are independently associated with diffuse low-grade glioma prognosis. Patients diagnosed with epileptic seizures and those with complete and early surgical resections have better oncological outcomes. Early and maximal surgical resection is thus required for diffuse low-grade gliomas, both for oncological and epileptological purposes. spa
dc.language.iso eng spa
dc.title Epileptic seizures in diffuse low-grade gliomas in adults spa
dc.type article spa
dc.description.impact 9.196 JCR (2014) Q1, 6/192 Clinical neurology, 14/252 Neurosciences spa
dc.identifier.doi 10.1093/brain/awt345 spa
dc.rights.accessRights closedAccess en
dc.subject.unesco Enfermedad del sistema nervioso spa
dc.subject.unesco Investigación sobre el cerebro spa
dc.description.filiation UEM spa
dc.peerreviewed Si spa


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