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ApoE gene and exceptional longevity: Insights from three independent cohorts

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dc.contributor.author Garatachea, Nuria
dc.contributor.author Emanuele, Enzo
dc.contributor.author Calero, Miguel
dc.contributor.author Fuku, Noriyuki
dc.contributor.author Arai, Yasumichi
dc.contributor.author Abe, Yukiko
dc.contributor.author Murakami, Haruka
dc.contributor.author Miyachi, Motohiko
dc.contributor.author Yvert, Thomas Paul
dc.contributor.author Verde Rello, Zoraida
dc.contributor.author Zea, María Ascensión
dc.contributor.author Venturini, Letizia
dc.contributor.author Santiago Dorrego, Catalina
dc.contributor.author Santos-Lozano, Alejandro
dc.contributor.author Rodríguez Romo, Gabriel
dc.contributor.author Ricevuti, Giovanni
dc.contributor.author Hirose, Nobuyoshi
dc.contributor.author Rábano, Alberto
dc.contributor.author Lucía Mulas, Alejandro
dc.date.accessioned 2014-04-11T10:37:10Z
dc.date.available 2014-04-11T10:37:10Z
dc.date.issued 2014 spa
dc.identifier.citation Garatachea, N., Emanuele, E., Calero, M., Fuku, N., Arai, Y., Abe, Y., ..., & Lucía-Mulas, A. (2014). ApoE gene and exceptional longevity: insights from three independent cohorts. Experimental Gerontology, 53, 16-23. spa
dc.identifier.issn 05315565 spa
dc.identifier.uri http://hdl.handle.net/11268/2753
dc.description.abstract The ApoE gene is associated with the risk of Alzheimer or cardiovascular disease but its influence on exceptional longevity (EL) is uncertain. Our primary purpose was to determine, using a case-control design, if the ApoE gene is associated with EL. We compared ApoE allele/genotype frequencies among the following cohorts: cases (centenarians, most with 1+ major disease condition; n=163, 100-111years) and healthy controls (n=1039, 20-85years) from Spain; disease-free cases (centenarians; n=79, 100-104years) and healthy controls (n=597, age 27-81years) from Italy; and cases (centenarians and semi-supercentenarians, most with 1+ major disease condition; n=729, 100-116years) and healthy controls (n=498, 23-59years) from Japan. Our main findings were twofold. First, the ε4-allele was negatively associated with EL in the three cohorts, with the following odds ratio (OR) values (adjusted by sex) having been found: 0.55 (95% confidence interval (CI): 0.33, 0.94), P=0.030 (Spain); 0.41 (95%CI: 0.18, 0.99), P=0.05 (Italy); and 0.35 (95%CI: 0.26, 0.57), P<0.001 (Japan). Second, although no association was found in the Spanish cohort (OR=1.42 (95%CI: 0.89, 2.26), P=0.145), the ε2-allele was positively associated with EL in the Italian (OR=2.14 (95%CI: 1.18, 3.45), P=0.01) and Japanese subjects (OR=1.81 (95%CI: 1.25, 2.63), P=0.002). Notwithstanding the limitations of case-control designs, our data suggest that the ApoE might be a candidate to influence EL. The ε4-allele appears to decrease the likelihood of reaching EL among individuals of different ethnic/geographic origins. An additional, novel finding of our study was that the ε2-allele might favor EL, at least in the Italian and Japanese cohorts. spa
dc.description.sponsorship PI12/00914 (Fondo de Investigaciones Sanitarias) spa
dc.language.iso eng spa
dc.title ApoE gene and exceptional longevity: Insights from three independent cohorts spa
dc.type article spa
dc.description.impact 3.485 JCR (2014) Q1, 12/50 Geriatrics & gerontology spa
dc.identifier.doi 10.1016/j.exger.2014.02.004 spa
dc.rights.accessRights openAccess spa
dc.subject.uem Envejecimiento spa
dc.subject.unesco Ciencia spa
dc.description.filiation UEM spa
dc.peerreviewed Si spa


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