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Dampened hippocampal oscillations and enhanced spindel activity in an assymptomatic model of developmental cortical malformations

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dc.contributor.author Cid, Elena
dc.contributor.author Gómez-Domínguez, Daniel
dc.contributor.author Martín-López, David
dc.contributor.author Gal Iglesias, Beatriz
dc.contributor.author Laurent, François
dc.contributor.author Ibarz, José M.
dc.contributor.author Francis, Fiona
dc.contributor.author Menéndez de la Prida, Liset
dc.date.accessioned 2014-04-23T15:38:53Z
dc.date.available 2014-04-23T15:38:53Z
dc.date.issued 2014 spa
dc.identifier.citation Cid, E., Gómez-Domínguez, D., Martín-López, D., Gal-Iglesias, B., Laurent, F., Ibarz, J. M., ..., & Menéndez-Prida, L. (2014). Dampened hippocampal oscillations and enhanced spindle activity in an asymptomatic model of developmental cortical malformations. Frontiers in Systems Neuroscience, 8. spa
dc.identifier.issn 16625137 spa
dc.identifier.uri http://hdl.handle.net/11268/2794
dc.description.abstract Developmental cortical malformations comprise a large spectrum of histopathological brain abnormalities and syndromes. Their genetic, developmental and clinical complexity suggests they should be better understood in terms of the complementary action of independently timed perturbations (i.e., the multiple-hit hypothesis). However, understanding the underlying biological processes remains puzzling. Here we induced developmental cortical malformations in offspring, after intraventricular injection of methylazoxymethanol (MAM) in utero in mice. We combined extensive histological and electrophysiological studies to characterize the model. We found that MAM injections at E14 and E15 induced a range of cortical and hippocampal malformations resembling histological alterations of specific genetic mutations and transplacental mitotoxic agent injections. However, in contrast to most of these models, intraventricularly MAM-injected mice remained asymptomatic and showed no clear epilepsy-related phenotype as tested in long-term chronic recordings and with pharmacological manipulations. Instead, they exhibited a non-specific reduction of hippocampal-related brain oscillations (mostly in CA1); including theta, gamma and HFOs; and enhanced thalamocortical spindle activity during non-REM sleep. These data suggest that developmental cortical malformations do not necessarily correlate with epileptiform activity. We propose that the intraventricular in utero MAM approach exhibiting a range of rhythmopathies is a suitable model for multiple-hit studies of associated neurological disorders. spa
dc.language.iso eng spa
dc.title Dampened hippocampal oscillations and enhanced spindel activity in an assymptomatic model of developmental cortical malformations spa
dc.type article spa
dc.description.impact 2.074 SJR (2014) Q1, 13/77 Cognitive neuroscience, 7/30 Developmental neuroscience, 27/140 Neuroscience (miscellaneous); Q2, 25/83 Cellular and mollecular neuroscience spa
dc.identifier.doi 10.3389/fnsys.2014.00050 spa
dc.rights.accessRights openAccess spa
dc.subject.uem Epilepsia spa
dc.subject.unesco Enfermedad del sistema nervioso spa
dc.description.filiation UEM spa
dc.peerreviewed Si spa


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