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Identification of CYP2D6 null variants among long-stay, chronic psychiatric inpatients: is it strictly necessary?

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dc.contributor.author Fernández Santander, Ana spa
dc.contributor.author Santiago Dorrego, Catalina spa
dc.contributor.author Díez-Durán, Sarai spa
dc.contributor.author González, María spa
dc.contributor.author Castro, Emilia de spa
dc.contributor.author Guijarro, Jorge spa
dc.contributor.author Bandrés Moya, Fernando spa
dc.contributor.author Lucía Mulas, Alejandro spa
dc.contributor.author Gómez Gallego, Félix spa
dc.date.accessioned 2013-11-27T17:25:57Z
dc.date.available 2013-11-27T17:25:57Z
dc.date.issued 2008 spa
dc.identifier.citation Fernández‐Santander, A., Santiago-Dorrego, C., Díez-Durán, S., González, M., Castro, E., Guijarro, J., ..., & Gómez-Gallego, F. (2008). Identification of CYP2D6 null variants among long‐stay, chronic psychiatric inpatients: Is it strictly necessary? Human Psychopharmacology: Clinical and Experimental, 23(6), 533-536. spa
dc.identifier.issn 10991077 spa
dc.identifier.uri http://hdl.handle.net/11268/317
dc.description.abstract We identified the null variants *3,*4,*5,*6,*7 and *8 of the CYP2D6 gene [encoding for cytochrome P450 (debrisoquine hydroxylase)] in a group of 84 chronic-stay psychiatric inpatients with severe schizophrenia or related disorders and receiving treatment with one or more CYP2D6 substrates for years. We also studied a group of 100 healthy controls of similar ethnic origin (Spanish Caucasians). Three patients were poor metabolizers (PMs) for antipsychotic drugs according to their CYP2D6 genotype (i.e. homozygous for the *4 allele) but they exhibited no adverse drug reaction over the years despite chronic treatment with CYP2D6 substrates. We suggest that CYP2D6 genetic screening is more useful in other type of psychiatric patients, particularly in younger ones starting treatment protocols. spa
dc.language.iso eng spa
dc.subject.other Cytochrome P-450 Cyp2d6/*Genetics spa
dc.subject.other Schizophrenia/*Genetics spa
dc.subject.other Alleles spa
dc.subject.other Chronic Disease spa
dc.subject.other Female spa
dc.subject.other Genetic Variation spa
dc.subject.other Genotype spa
dc.subject.other Humans spa
dc.subject.other Male spa
dc.subject.other Middle Aged spa
dc.title Identification of CYP2D6 null variants among long-stay, chronic psychiatric inpatients: is it strictly necessary? spa
dc.type article spa
dc.description.impact 2.080 JCR (2008) Q3, 78/156 Clinical neurology, 125/219 Pharmacology and pharmacy, 61/101 Psychiatry, 31/61 Psychology spa
dc.identifier.doi 10.1002/hup.943 spa
dc.rights.accessRights openAccess en
dc.subject.unesco Psiquiatría spa
dc.description.filiation UEM spa
dc.peerreviewed Si spa


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