Altered metabolic and stemness capacity of adipose tissue-derived stem cells from obese mouse and human

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dc.contributor.author Pérez, Laura M.
dc.contributor.author Bernal, Aurora
dc.contributor.author Lucas, Beatriz de
dc.contributor.author San Martín, Nuria
dc.contributor.author Mastrangelo, Annalaura
dc.contributor.author García, Antonia
dc.contributor.author Barbas, Coral
dc.contributor.author González Gálvez, Beatriz
dc.date.accessioned 2015-05-27T07:08:37Z
dc.date.available 2015-05-27T07:08:37Z
dc.date.issued 2015
dc.identifier.citation Pérez, L. M., Bernal, A., de Lucas, B., San Martin, N., Mastrangelo, A., García, A., ... & Gálvez, B. G. (2015). Altered Metabolic and Stemness Capacity of Adipose Tissue-Derived Stem Cells from Obese Mouse and Human. PloS One, 10(4). spa
dc.identifier.issn 19326203
dc.identifier.uri http://hdl.handle.net/11268/3955
dc.description.abstract Adipose stem cells (ASCs) are an appealing source of cells for therapeutic intervention; however, the environment from which ASCs are isolated may impact their usefulness. Using a range of functional assays, we have evaluated whether ASCs isolated from an obese environment are comparable to cells from non-obese adipose tissue. Results showed that ASCs isolated from obese tissue have a reduced proliferative ability and a loss of viability together with changes in telomerase activity and DNA telomere length, suggesting a decreased self-renewal capacity. Metabolic analysis demonstrated that mitochondrial content and function was impaired in obese-derived ASCs resulting in changes in favored oxidative substrates. These findings highlight the impact of obesity on adult stem properties. Hence, caution should be exercised when considering the source of ASCs for cellular therapies since their therapeutic potential may be impaired. spa
dc.language.iso eng spa
dc.rights Atribución-NoComercial-SinDerivadas 3.0 España *
dc.rights.uri http://creativecommons.org/licenses/by-nc-nd/3.0/es/ *
dc.title Altered metabolic and stemness capacity of adipose tissue-derived stem cells from obese mouse and human spa
dc.type article spa
dc.description.impact 3.057 JCR (2015) Q1, 11/63 Multidisciplinary sciences spa
dc.identifier.doi 10.1371/journal.pone.0123397
dc.rights.accessRights openAccess spa
dc.subject.uem Células madre spa
dc.subject.uem Genética spa
dc.subject.unesco Genética spa
dc.description.filiation UEM spa
dc.peerreviewed Si spa

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