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Understanding graft-versus-host disease. Preliminary findings regarding the effects of exercise in affected patients

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dc.contributor.author Fiuza Luces, María del Carmen
dc.contributor.author Garatachea, Nuria
dc.contributor.author Simpson, Richard J.
dc.contributor.author Berger, Nathan A.
dc.contributor.author Ramírez, Manuel
dc.contributor.author Lucía Mulas, Alejandro
dc.date.accessioned 2015-05-27T15:00:06Z
dc.date.available 2015-05-27T15:00:06Z
dc.date.issued 2015
dc.identifier.citation Fiuza-Luces, C., Garatachea, N., Simpson, R. J., Berger, N. A., Ramírez, M., & Lucia, A. (2014). Understanding graft-versus-host disease. Preliminary findings regarding the effects of exercise in affected patients. Exercise Immunology Review, 21, 80-112. spa
dc.identifier.issn 10775552
dc.identifier.uri http://hdl.handle.net/11268/3970
dc.description.abstract Advances in this century regarding allogeneic hematopoietic stem cell transplantation (allo-HSCT) have led to an expanding population of long-term survivors, many of whom suffer severe side effects, particularly those related to graft-versushost disease (GVHD), a potentially multi-systemic disorder caused by immunoeffector donor lymphocytes that destroy host tissues. The GVHD, especially in its chronic form (cGVHD), generates considerable morbidity and compromises the physical capacity of patients. We have reviewed the main pathophysiological aspects of the disease as well as the data available on the effects of exercise in GVHD, based on animal and human patient research. Although exercise training as an adjunct therapy to improve health outcomes after allo-HSCT shows promise (particularly, this lifestyle intervention can improve physical fitness and possibly immune function while attenuating fatigue), there is a need for more randomized control trials that focus specifically on GVHD spa
dc.description.sponsorship PI12/00914 (Fondo de Investigaciones Sanitarias) spa
dc.language.iso eng spa
dc.title Understanding graft-versus-host disease. Preliminary findings regarding the effects of exercise in affected patients spa
dc.type article spa
dc.description.impact 4.294 JCR (2015) Q1, 5/82 Sport sciences; Q2, 39/150 Immunology spa
dc.rights.accessRights openAccess spa
dc.subject.uem Condición física spa
dc.subject.uem Ejercicio físico spa
dc.subject.unesco Educación física spa
dc.subject.unesco Salud spa
dc.description.filiation UEM spa
dc.relation.publisherversion http://www.medizin.uni-tuebingen.de/transfusionsmediz in/institut/eir/content/2015/80/article.pdf spa
dc.peerreviewed Si spa


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