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FNDC5 (irisin) gene and exceptional longevity: a functional replication study with rs16835198 and rs726344 SNPs

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dc.contributor.author Sanchís-Gomar, Fabián
dc.contributor.author Garatachea, Nuria
dc.contributor.author Zi-Hong, He
dc.contributor.author Pareja Galeano, Helios
dc.contributor.author Fuku, Noriyuki
dc.contributor.author Tian, Ye
dc.contributor.author Arai, Yasumichi
dc.contributor.author Abe, Yukiko
dc.contributor.author Murakami, Haruka
dc.contributor.author Miyachi, Motohiko
dc.contributor.author Yvert, Thomas Paul
dc.contributor.author Santiago Dorrego, Catalina
dc.contributor.author Venturini, Letizia
dc.contributor.author Fiuza Luces, María del Carmen
dc.contributor.author Santos-Lozano, Alejandro
dc.contributor.author Rodríguez, Gabriel
dc.contributor.author Ricevuti, Giovanni
dc.contributor.author Hirose, Nobuyoshi
dc.contributor.author Emanuele, Enzo
dc.contributor.author Lucía Mulas, Alejandro
dc.date.accessioned 2015-06-15T07:03:48Z
dc.date.available 2015-06-15T07:03:48Z
dc.date.issued 2014
dc.identifier.citation Sanchis-Gomar, F., Garatachea, N., He, Z. H., Pareja-Galeano, H., Fuku, N., Tian, Y., ..., & Lucía-Mulas, A. (2014). FNDC5 (irisin) gene and exceptional longevity: a functional replication study with rs16835198 and rs726344 SNPs. AGE, 36(6), 1-12. spa
dc.identifier.issn 01619152
dc.identifier.uri http://hdl.handle.net/11268/3986
dc.description.abstract Irisin might play an important role in reducing the risk of obesity, insulin resistance, or several related diseases, and high irisin levels may contribute to successful aging. Thus, the irisin precursor (FNDC5) gene is a candidate to influence exceptional longevity (EL), i.e., being a centenarian. It has been recently shown that two single-nucleotide polymorphisms (SNPs) in the FNDC5 gene, rs16835198 and rs726344, are associated with in vivo insulin sensitivity in adults. We determined luciferase gene reporter activity in the two above-mentioned SNPs and studied genotype distributions among centenarians (n = 175, 144 women) and healthy controls (n = 347, 142 women) from Spain. We also studied an Italian [79 healthy centenarians (40 women) and 316 healthy controls (156 women)] and a Japanese cohort [742 centenarians (623 women) and 499 healthy controls (356 women)]. The rs726344 SNP had functional significance, as shown by differences in luciferase activity between the constructs of this SNP (all P ≤ 0.05), with the variant A-allele having higher luciferase activity compared with the G-allele (P = 0.04). For the rs16835198 SNP, the variant T-allele tended to show higher luciferase activity compared with the G-allele (P = 0.07). However, we found no differences between genotype/allele frequencies of the two SNPs in centenarians versus controls in any cohort, and no significant association (using logistic regression adjusted by sex) between the two SNPs and EL. Further research is needed with different cohorts as well as with additional variants in the FNDC5 gene or in other genes involved in irisin signaling. spa
dc.language.iso eng spa
dc.title FNDC5 (irisin) gene and exceptional longevity: a functional replication study with rs16835198 and rs726344 SNPs spa
dc.type article spa
dc.description.impact 3.390 JCR (2014) Q2, 14/50 Geriatrics & gerontology spa
dc.identifier.doi 10.1007/s11357-014-9733-1
dc.rights.accessRights openAccess spa
dc.subject.uem Envejecimiento spa
dc.subject.uem Ancianos - Ejercicio físico spa
dc.subject.unesco Envejecimiento spa
dc.subject.unesco Educación física spa
dc.description.filiation UEM spa
dc.peerreviewed Si spa


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