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Exceptional longevity and muscle and fitness related genotypes: a functional in vitro analysis and case-control association replication study with SNPs THRH rs7832552, IL6 rs1800795 and ACSL1 rs6552828

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dc.contributor.author Fuku, Noriyuki
dc.contributor.author He, Zi-Hong
dc.contributor.author Sanchís-Gomar, Fabián
dc.contributor.author Pareja Galeano, Helios
dc.contributor.author Tian, Ye
dc.contributor.author Arai, Yasumichi
dc.contributor.author Abe, Yukiko
dc.contributor.author Murakami, Haruka
dc.contributor.author Miyachi, Motohiko
dc.contributor.author Zempo, Hirofumi
dc.contributor.author Naito, Hisashi
dc.contributor.author Yvert, Thomas Paul
dc.contributor.author Verde Rello, Zoraida
dc.contributor.author Venturini, Letizia
dc.contributor.author Fiuza Luces, María del Carmen
dc.contributor.author Santos-Lozano, Alejandro
dc.contributor.author Rodríguez Romo, Gabriel
dc.contributor.author Ricevuti, Giovanni
dc.contributor.author Hirose, Nobuyoshi
dc.contributor.author Emanuele, Enzo
dc.contributor.author Garatachea, Nuria
dc.contributor.author Lucía Mulas, Alejandro
dc.date.accessioned 2015-06-15T10:14:11Z
dc.date.available 2015-06-15T10:14:11Z
dc.date.issued 2015
dc.identifier.citation Fuku, N., He, Z. H., Sanchis-Gomar, F., Pareja-Galeano, H., Tian, Y., Arai, Y., ... & Lucia, A. (2015). Exceptional longevity and muscle and fitness related genotypes: a functional in vitro analysis and case-control association replication study with SNPs THRH rs7832552, IL6 rs1800795, and ACSL1 rs6552828. Frontiers in aging neuroscience, 7. spa
dc.identifier.issn 16634365
dc.identifier.uri http://hdl.handle.net/11268/3997
dc.description.abstract There are several gene variants that are candidates to influence functional capacity in long-lived individuals. As such, their potential association with exceptional longevity (EL, i.e., reaching 100+ years) deserves analysis. Among them are rs7832552 in the thyrotropin-releasing hormone receptor (TRHR) gene, rs1800795 in the interleukin-6 (IL6) gene and rs6552828 in the coenzyme A synthetase long-chain 1 (ACSL1) gene. To gain insight into their functionality (which is yet unknown), here we determined for the first time luciferase gene reporter activity at the muscle tissue level in rs7832552 and rs6552828. We then compared allele/genotype frequencies of the 3 abovementioned variants among centenarians [n = 138, age range 100-111 years (114 women)] and healthy controls [n = 334, 20-50 years (141 women)] of the same ethnic and geographic origin (Spain). We also studied healthy centenarians [n = 79, 100-104 years (40 women)] and controls [n = 316, 27-81 years (156 women)] from Italy, and centenarians [n = 742, 100-116 years (623 women)] and healthy controls [n = 499, 23-59 years (356 women)] from Japan. spa
dc.language.iso eng spa
dc.rights Reconocimiento 4.0 Internacional *
dc.rights.uri https://creativecommons.org/licenses/by/4.0/deed.es_ES *
dc.subject.other Centenarians spa
dc.subject.other Polymorphisms spa
dc.subject.other Muscle and sarcopenia spa
dc.title Exceptional longevity and muscle and fitness related genotypes: a functional in vitro analysis and case-control association replication study with SNPs THRH rs7832552, IL6 rs1800795 and ACSL1 rs6552828 spa
dc.type article spa
dc.description.impact 4.348 JCR (2015) Q1, 6/49 Geriatrics & gerontology, 60/256 Neurosciences spa
dc.identifier.doi 10.3389/fnagi.2015.00059
dc.rights.accessRights openAccess spa
dc.subject.uem Envejecimiento spa
dc.subject.uem Ejercicio físico spa
dc.subject.unesco Envejecimiento spa
dc.subject.unesco Deporte spa
dc.subject.unesco Salud spa
dc.description.filiation UEM spa
dc.peerreviewed Si spa


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Reconocimiento 4.0 Internacional Except where otherwise noted, this item's license is described as Reconocimiento 4.0 Internacional