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McArdle disease does not affect skeletal muscle fibre type profiles in human

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dc.contributor.author Kohn, Tertius A.
dc.contributor.author Noakes, Timothy D.
dc.contributor.author Rae, Dale E.
dc.contributor.author Rubio, Juan Carlos
dc.contributor.author Santalla Hernández, Alfredo
dc.contributor.author Nogales-Gadea, Gisela
dc.contributor.author Pinós, Tomás
dc.contributor.author Martín, Miguel Ángel
dc.contributor.author Arenas, Joaquín
dc.contributor.author Lucía Mulas, Alejandro
dc.date.accessioned 2015-06-16T07:59:01Z
dc.date.available 2015-06-16T07:59:01Z
dc.date.issued 2014
dc.identifier.citation Kohn, T. A., Noakes, T. D., Rae, D. E., Rubio, J. C., Santalla-Hernández, A., Nogales-Gadea, G., ..., & Lucía-Mulas, A. (2014). McArdle disease does not affect skeletal muscle fibre type profiles in humans. Biology Open, 3(12), 1224-1227. spa
dc.identifier.issn 20466390
dc.identifier.uri http://hdl.handle.net/11268/4002
dc.description.abstract Patients suffering from glycogen storage disease V (McArdle disease) were shown to have higher surface electrical activity in their skeletal muscles when exercising at the same intensity as their healthy counterparts, indicating more muscle fibre recruitment. To explain this phenomenon, this study investigated whether muscle fibre type is shifted towards a predominance in type I fibres as a consequence of the disease. Muscle biopsies from the Biceps brachii (BB) (n = 9) or Vastus lateralis (VL) (n = 8) were collected over a 13-year period from male and female patients diagnosed with McArdle disease, analysed for myosin heavy chain (MHC) isoform content using SDS-PAGE, and compared to healthy controls (BB: n = 3; VL: n = 10). All three isoforms were expressed and no difference in isoform expression in VL was found between the McArdle patients and healthy controls (MHC I: 33±19% vs. 43±7%; MHC IIa: 52±9% vs. 40±7%; MHC IIx: 15±18% vs. 17±9%). spa
dc.description.sponsorship Proyecto PI12/00914 (Fondo de Investigaciones Sanitarias) spa
dc.language.iso eng spa
dc.rights Reconocimiento 3.0 Unported *
dc.rights.uri https://creativecommons.org/licenses/by/3.0/deed.es_ES *
dc.subject.other Myosin heavy chain spa
dc.subject.other Glycogen storage disease V spa
dc.subject.other Phosphorylase deficiency spa
dc.title McArdle disease does not affect skeletal muscle fibre type profiles in human spa
dc.type article spa
dc.description.impact 2.416 JCR (2014) Q2, 22/85 Biology spa
dc.identifier.doi 10.1242/bio.20149548
dc.rights.accessRights openAccess spa
dc.subject.uem Enfermedades - McArdle spa
dc.subject.uem Ejercicio físico spa
dc.subject.uem Genética spa
dc.subject.unesco Ciencia spa
dc.subject.unesco Salud spa
dc.subject.unesco Genética humana spa
dc.description.filiation UEM spa
dc.peerreviewed Si spa


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Reconocimiento 3.0 Unported Except where otherwise noted, this item's license is described as Reconocimiento 3.0 Unported