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Comorbidity and intervention in octogenarians with severe symptomatic aortic stenosis

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dc.contributor.author Martínez Sellés Oliveria Soares, Manuel
dc.contributor.author Díez-Villanueva, Pablo
dc.contributor.author Sánchez-Sendin, Domingo
dc.contributor.author Carro Hevia, Amelia
dc.contributor.author Gómez Doblas, J. J.
dc.contributor.author García de la Villa, Bernardo
dc.contributor.author Cornide, L.
dc.contributor.author Alonso Tello, Albert
dc.contributor.author Andión Ogando, Ramón
dc.contributor.author Ripoll Vera, Tomás
dc.contributor.author Arribas Jiménez, Antonio
dc.contributor.author Carrillo, P.
dc.contributor.author Rodríguez Pascual, Carlos
dc.contributor.author Casares i Romeva, María
dc.contributor.author Borras, X.
dc.contributor.author Vázquez, Sandra
dc.contributor.author López Palop, Ramón
dc.date.accessioned 2015-06-17T14:43:53Z
dc.date.available 2015-06-17T14:43:53Z
dc.date.issued 2015
dc.identifier.citation Martínez-Sellés, M., Díez-Villanueva, P., Sánchez-Sendin, D., Hevia, A. C., Doblas, J. J. G., de la Villa, B. G., ... & Group, P. R. (2015). Comorbidity and intervention in octogenarians with severe symptomatic aortic stenosis. International Journal of Cardiology, 189, 61-66. spa
dc.identifier.issn 01675273
dc.identifier.uri http://hdl.handle.net/11268/4015
dc.description.abstract Background The benefit from intervention in elderly patients with symptomatic severe aortic stenosis (AS) and high comorbidity is unknown. Our aims were to establish the correlation between the Charlson comorbidity index and the prognosis of octogenarians with symptomatic sever AS and to identify patients who might not benefit from intervention. Methods We used the data from PEGASO (Pronóstico de la Estenosis Grave Aórtica Sintomática del Octogenario — Prognosis of symptomatic severe aortic stenosis in octogenarians), a prospective registry that included consecutively 928 patients aged ≥ 80 years with severe symptomatic AS. Results The mean Charlson comorbidity index was 3.0 ± 1.7, a total of 151 patients (16.3%) presented high comorbidity (index ≥ 5). Median survival was lower for patients with high comorbidity than for those without (16.7 ± 1.2 vs. 26.5 ± 0.6 months, p < 0.001). In patients without high comorbidity planned interventional management was clearly associated with prognosis (log rank p < 0.001), which was not the case in patients with high comorbidity (log rank p > 0.10). In multivariate analysis, the only variables that were independently associated with prognosis were planned medical management and Charlson index. Patients with high comorbidity presented non-cardiac death more frequently than those who had not (28.6% vs. 19.5%, p = 0.008). Conclusions One sixth of octogenarians with symptomatic severe AS have very high comorbidity (Charlson index ≥ 5). These patients have a poor prognosis in the short term and do not seem to benefit from interventional treatment. spa
dc.language.iso eng spa
dc.subject.other Aorta spa
dc.subject.other Estenosis spa
dc.title Comorbidity and intervention in octogenarians with severe symptomatic aortic stenosis spa
dc.type article spa
dc.description.impact 4.638 JCR (2015) Q1, 24/124 Cardiac and cardiovascular systems spa
dc.identifier.doi 10.1016/j.ijcard.2015.04.017
dc.rights.accessRights closedAccess spa
dc.subject.uem Cardiología spa
dc.subject.uem Acianos spa
dc.subject.unesco Sistema cardiovascular spa
dc.subject.unesco Anciano spa
dc.description.filiation UEM spa
dc.peerreviewed Si spa


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