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Donor/recipient sex mismatch and survival after heart transplantation: only an issue in male recipients? An analysis of the Spanish Heart Transplantation Registry

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dc.contributor.author Martínez Sellés Oliveria Soares, Manuel
dc.contributor.author Almenar, Luís
dc.contributor.author Paniagua-Martín, Maria J.
dc.contributor.author Segovia Cubero, Javier
dc.contributor.author Delgado, Juan F.
dc.contributor.author Arizón, Jose M.
dc.contributor.author Ayesta, Ana
dc.contributor.author Lage, Ernesto
dc.contributor.author Brossa, Vicens
dc.contributor.author Manito, Nicolás
dc.contributor.author Pérez-Villa, Félix
dc.contributor.author Diaz Molina, Beatriz
dc.contributor.author Rábago, Gregorio
dc.contributor.author Blasco-Peiró, Teresa
dc.contributor.author Fuente Galán, Luís de la
dc.contributor.author Pascual-Figal, Domingo
dc.contributor.author González-Vilchez, Francisco
dc.date.accessioned 2015-06-17T15:08:33Z
dc.date.available 2015-06-17T15:08:33Z
dc.date.issued 2014
dc.identifier.citation Martínez‐Sellés, M., Almenar, L., Paniagua‐Martín, M. J., Segovia, J., Delgado, J. F., Arizón, J. M., ..., & González‐Vilchez, F. (2014). Donor/recipient sex mismatch and survival after heart transplantation: only an issue in male recipients? An analysis of the Spanish Heart Transplantation Registry. Transplant International, 28(3), 305-313. spa
dc.identifier.issn 14322277
dc.identifier.uri http://hdl.handle.net/11268/4017
dc.description.abstract The results of studies on the association between sex mismatch and survival after heart transplantation are conflicting. Data from the Spanish Heart Transplantation Registry. From 4625 recipients, 3707 (80%) were men. The donor was female in 943 male recipients (25%) and male in 481 female recipients (52%). Recipients of male hearts had a higher body mass index (25.9 ± 4.1 vs. 24.3 ± 3.7; P < 0.01), and male donors were younger than female donors (33.4 ± 12.7 vs. 38.2 ± 12.3; P < 0.01). No further relevant differences related to donor sex were detected. In the univariate analysis, mismatch was associated with mortality in men (hazard ratio [HR], 1.18; 95% confidence interval [CI], 1.06–1.32; P = 0.003) but not in women (HR, 0.91; 95% CI 0.74–1.12; P = 0.4). A significant interaction was detected between sex mismatch and recipient gender (P = 0.02). In the multivariate analysis, sex mismatch was associated with long-term mortality (HR, 1.14; 95% CI 1.01–1.29; P = 0.04), and there was a tendency toward significance for the interaction between sex mismatch and recipient gender (P = 0.08). In male recipients, mismatch increased mortality mainly during the first month and in patients with pulmonary gradient >13 mmHg. Sex mismatch seems to be associated with mortality after heart transplantation in men but not in women. spa
dc.language.iso eng spa
dc.subject.other Trasplante de corazón spa
dc.title Donor/recipient sex mismatch and survival after heart transplantation: only an issue in male recipients? An analysis of the Spanish Heart Transplantation Registry spa
dc.type article spa
dc.description.impact 2.599 JCR (2014) Q2, 50/198 Surgery; Q3, 13/25 Transplantation spa
dc.identifier.doi 10.1111/tri.12488
dc.rights.accessRights openAccess spa
dc.subject.uem Cardiología spa
dc.subject.unesco Sistema cardiovascular spa
dc.description.filiation UEM spa
dc.relation.publisherversion http://dx.doi.org/10.1111/tri.12488 spa
dc.peerreviewed Si spa


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