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Anticancer and antiangiogenic activity of surfactant-free nanoparticles based on self-assembled polymeric derivatives of vitamin e: Structure-activity relationship

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dc.contributor.author Palao Suay, Raquel
dc.contributor.author Aguilar de Armas, María Rosa
dc.contributor.author Parra Ruiz, F. J.
dc.contributor.author Fernández Gutiérrez, M.
dc.contributor.author Parra, J.
dc.contributor.author Sánchez Rodríguez, Carolina
dc.contributor.author Sanz Fernández, Ricardo
dc.contributor.author Rodrigáñez Riesco, Laura
dc.contributor.author Román, J. S.
dc.date.accessioned 2015-06-19T07:12:43Z
dc.date.available 2015-06-19T07:12:43Z
dc.date.issued 2015
dc.identifier.citation Palao-Suay, R., Aguilar, M. R., Parra-Ruiz, F. J., Fernández-Gutiérrez, M., Parra, J., Sánchez-Rodríguez, C., ... & Román, J. S. (2015). Anticancer and Antiangiogenic Activity of Surfactant-Free Nanoparticles Based on Self-Assembled Polymeric Derivatives of Vitamin E: Structure–Activity Relationship. Biomacromolecules, 16(5), 1566-1581. spa
dc.identifier.issn 15257797
dc.identifier.issn 15264602
dc.identifier.uri http://hdl.handle.net/11268/4020
dc.description.abstract α-Tocopheryl succinate (α-TOS) is a well-known mitochondrially targeted anticancer compound, however, it is highly hydrophobic and toxic. In order to improve its activity and reduce its toxicity, new surfactant-free biologically active nanoparticles (NP) were synthesized. A methacrylic derivative of α-TOS (MTOS) was prepared and incorporated in amphiphilic pseudoblock copolymers when copolymerized with N-vinylpyrrolidone (VP) by free radical polymerization (poly(VP-co-MTOS)). The selected poly(VP-co-MTOS) copolymers formed surfactant-free NP by nanoprecipitation with sizes between 96 and 220 nm and narrow size distribution, and the in vitro biological activity was tested. In order to understand the structure-activity relationship three other methacrylic monomers were synthesized and characterized: MVE did not have the succinate group, SPHY did not have the chromanol ring, and MPHY did not have both the succinate group and the chromanol ring. spa
dc.language.iso eng spa
dc.title Anticancer and antiangiogenic activity of surfactant-free nanoparticles based on self-assembled polymeric derivatives of vitamin e: Structure-activity relationship spa
dc.type article spa
dc.description.impact 5.583 JCR (2015) Q1, 41/289 Biochemistry & molecular biology, 6/59 Chemistry, organic, 5/82 Polymer science spa
dc.identifier.doi 10.1021/acs.biomac.5b00130
dc.rights.accessRights closedAccess spa
dc.subject.uem Vitaminas spa
dc.subject.uem Cáncer spa
dc.subject.unesco Salud spa
dc.subject.unesco Ciencias médicas spa
dc.subject.unesco Cáncer spa
dc.subject.unesco Vitamina spa
dc.description.filiation UEM spa
dc.peerreviewed Si spa


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