Effects of cigarette smoking and nicotine metabolite ratio on leukocyte telomere length

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dc.contributor.author Verde Rello, Zoraida
dc.contributor.author Reinoso Barbero, Luis
dc.contributor.author Chicharro García, Luis Miguel
dc.contributor.author Garatachea, Nuria
dc.contributor.author Resano, Pilar
dc.contributor.author Sánchez Hernández, Ignacio Manuel
dc.contributor.author Rodríguez González-Moro, José Miguel
dc.contributor.author Bandrés Moya, Fernando
dc.contributor.author Santiago Dorrego, Catalina
dc.contributor.author Gómez Gallego, Félix
dc.date.accessioned 2015-09-01T07:24:05Z
dc.date.available 2015-09-01T07:24:05Z
dc.date.issued 2015
dc.identifier.citation Verde, Z., Reinoso-Barbero, L., Chicharro, L., Garatachea, N., Resano, P., Sánchez-Hernández, I., ... & Gómez-Gallego, F. (2015). Effects of cigarette smoking and nicotine metabolite ratio on leukocyte telomere length. Environmental Research, 140, 488-494. spa
dc.identifier.issn 00139351
dc.identifier.issn 10960953
dc.identifier.uri http://hdl.handle.net/11268/4289
dc.description.abstract Studies of the effects of smoking on leukocyte telomere length (LTL) using cigarettes smoked per day or pack years smoked (PYS) present limitations. Reported high levels of smoking may not increase toxin exposure levels proportionally. Nicotine metabolism ratio (NMR) predicts total cigarette puff volume and overall exposure based on total N-nitrosamines, is highly reproducible and independent of time since the last cigarette. We hypothesized that smokers with higher NMRs will exhibit increased total puff volume, reflecting efforts to extract more nicotine from their cigarettes and increasing toxin exposure. In addition, higher levels of smoking could cause a gross damage in LTL. The urinary cotinine, 3-OH cotinine and nicotine levels of 147 smokers were analyzed using a LC/MS system Triple-Q6410. LTL and CYP2A6 genotype was determined by PCR in blood samples. We found a significant association between NMR and CYP2A6 genotype. Reduction in LTL was seen in relation to accumulated tobacco consumption and years smoking when we adjusted for age and gender. However, there were no significant differences between NMR values and LTL. In our study the higher exposure was associated with lower number of PYS. Smokers with reduced cigarette consumption may exhibit compensatory smoking behavior that results in no reduced tobacco toxin exposure. Our results suggest that lifetime accumulated smoking exposure could cause a gross damage in LTL rather than NMR or PYS. Nevertheless, a combination of smoking topography (NMR) and consumption (PYS) measures may provide useful information about smoking effects on health outcomes. spa
dc.language.iso eng spa
dc.title Effects of cigarette smoking and nicotine metabolite ratio on leukocyte telomere length spa
dc.type article spa
dc.description.impact 3.088 JCR (2015) Q1, 31/172 Public, environmental & occupational health; Q2, 57/225 Environmental sciences spa
dc.identifier.doi 10.1016/j.envres.2015.05.008
dc.rights.accessRights closedAccess spa
dc.subject.uem Tabaco spa
dc.subject.uem Nicotina spa
dc.subject.unesco Biología molecular spa
dc.description.filiation UEM spa
dc.peerreviewed Si spa

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