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Clinicopathological Study of Regressed Testicular Tumors (Apparent Extragonadal Germ Cell Neoplasms)

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dc.contributor.author Angulo Cuesta, Javier spa
dc.contributor.author González, Javier spa
dc.contributor.author Rodríguez, Nuria spa
dc.contributor.author Hernández, Emilio spa
dc.contributor.author Núñez-Mora, Carlos spa
dc.contributor.author Rodríguez-Barbero, José M. spa
dc.contributor.author Santana, Alicia spa
dc.contributor.author López, José Ignacio spa
dc.date.accessioned 2013-11-27T17:26:08Z
dc.date.available 2013-11-27T17:26:08Z
dc.date.issued 2009 spa
dc.identifier.citation Angulo-Cuesta, J., González, J., Rodríguez, N., Hernández, E., Núñez-Mora, C., Rodríguez-Barbero, J. M., ..., & López, J. I. (2009). Clinicopathological study of regressed testicular tumors (apparent extragonadal germ cell neoplasms). The Journal of Urology, 182(5), 2303-2310. spa
dc.identifier.issn 00225347 spa
dc.identifier.uri http://hdl.handle.net/11268/474
dc.description.abstract Purpose: Testicular germ cell tumors sometimes regress spontaneously and manifest exclusively by metastasis. We report our experience with extragonadal germ cell tumors of probable testicular origin to study the frequency of this entity, and clinical, ultrasound and histopathological. correlations in a series of patients. Materials and Methods: A retrospective 16-year review of 1.2 million inhabitants in Spain revealed 17 with regressed testicular tumors treated at a total of 4 institutions. We analyzed clinical information, ultrasound features and histopathological. characteristics of testicular lesions and metastasis, and highlight the main findings. Results: A primary testicular origin was confirmed in all cases. This entity is more common than initially suspected since it accounts for 4% of consecutive germ cell tumors. Clinical manifestations varied according to metastatic site with an abdominal palpable mass (47% of cases), loin pain (35%) and transient testicular pain (29%) the most common complaints. No evidence of testicular neoplasms was found on physical examination in any case. Metastasis histology was nonseminomatous in 53% of cases, pure seminoma in 29% and mixed in 18%. The most common ultrasound features were calcifications in 65% of cases, hyperechogenic linear images in 59% and hypoechogenic nodular areas in 41%. Histological findings consisted of fibrotic areas in 100% of cases, hemosiderin deposits in 65%, seminiferous tubule atrophy in 59% and psammoma bodies in 29%. In testicular parenchyma or spermatic chord intratubular neoplasms and viable tumor foci were also noted (47% and 41% of cases, respectively). Conclusions: Spontaneous regression of a germ cell testicular tumor should be considered in each patient with extragonadal germ cell neoplasms. Ultrasound diagnosis of and surgical treatment for these primary testicular tumors appear critical to prevent relapse because residual disease develops in a significant proportion of cases. spa
dc.language.iso eng spa
dc.subject.other Testis spa
dc.subject.other Testicular Neoplasms spa
dc.subject.other Neoplasms spa
dc.subject.other Germ Cell and Embryonal spa
dc.subject.other Neoplasm Regression spa
dc.subject.other Spontaneous spa
dc.subject.other Ultrasonography spa
dc.subject.other Cancer spa
dc.subject.other Chemotherapy spa
dc.subject.other Orchiectomy spa
dc.subject.other Metastases spa
dc.subject.other Seminoma spa
dc.subject.other Growth spa
dc.subject.other Urology & Nephrology spa
dc.title Clinicopathological Study of Regressed Testicular Tumors (Apparent Extragonadal Germ Cell Neoplasms) spa
dc.type article spa
dc.description.impact 4.016 JCR (2009) Q1, 8/63 Neurology & nephrology spa
dc.identifier.doi 10.1016/j.juro.2009.07.045 spa
dc.rights.accessRights closedAccess en
dc.subject.unesco Cáncer spa
dc.subject.unesco Investigación médica spa
dc.peerreviewed Si spa


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