iPSCs-based anti-aging therapies: Recent discoveries and future challenges

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dc.contributor.author Pareja Galeano, Helios
dc.contributor.author Sanchís-Gomar, Fabián
dc.contributor.author Pérez, Laura M.
dc.contributor.author Emanuele, Enzo
dc.contributor.author Lucía Mulas, Alejandro
dc.contributor.author González Gálvez, Beatriz
dc.contributor.author Gallardo, María Esther
dc.date.accessioned 2016-03-07T12:11:39Z
dc.date.available 2016-03-07T12:11:39Z
dc.date.issued 2016
dc.identifier.citation Pareja-Galeano, H., Sanchís-Gomar, F., Pérez, L. M., Emanuele, E., Lucía, A., González, B., & Gallardo, M. E. (2016). iPSCs-based anti-aging therapies: Recent discoveries and future challenges. Ageing Research Reviews, 27(May), 37-41. spa
dc.identifier.issn 1568-1637
dc.identifier.uri http://hdl.handle.net/11268/5009
dc.description.abstract The main biological hallmarks of the aging process include stem cell exhaustion and cellular senescence. Consequently, research efforts to treat age-related diseases as well as anti-aging therapies in general have recently focused on potential 'reprogramming' regenerative therapies. These new approaches are based on induced pluripotent stem cells (iPSCs), including potential in vivo reprogramming for tissue repair. Another possibility is targeting pathways of cellular senescence, e.g., through modulation of p16INK4a signaling and especially inhibition of the nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB). Here, we reviewed and discussed these recent developments together with their possible usefulness for future treatments against sarcopenia, a major age-related condition. spa
dc.description.sponsorship PI15/00558 spa
dc.language.iso eng spa
dc.title iPSCs-based anti-aging therapies: Recent discoveries and future challenges spa
dc.type article spa
dc.description.impact 7.452 JCR (2016) Q1, 1/49 Geriatrics and Gerontology, 29/190 Cell Biology spa
dc.identifier.doi 10.1016/j.arr.2016.02.007
dc.rights.accessRights closedAccess spa
dc.subject.uem Geriatría spa
dc.subject.unesco Gerontología spa
dc.subject.unesco Salud spa
dc.description.filiation UEM spa
dc.peerreviewed Si spa

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