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Trace elements levels in centenarian ‘dodgers’

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dc.contributor.author Alis, Rafael
dc.contributor.author Santos-Lozano, Alejandro
dc.contributor.author Sanchís-Gomar, Fabián
dc.contributor.author Pareja Galeano, Helios
dc.contributor.author Fiuza Luces, María del Carmen
dc.contributor.author Garatachea, Nuria
dc.contributor.author Lucía Mulas, Alejandro
dc.contributor.author Emanuele, Enzo
dc.date.accessioned 2016-03-17T12:50:15Z
dc.date.available 2016-03-17T12:50:15Z
dc.date.issued 2016
dc.identifier.citation Alis, R., Santos-Lozano, A., Sanchís-Gomar, F., Pareja-Galeano, H., Fiuza-Luces, C., Garatachea, N., Lucía, A., & Emanuele, E. (2016). Trace elements levels in centenarian ‘dodgers’. Journal of Trace Elements in Medicine and Biology, 35(2), 103-106. DOI: 10.1016/j.jtemb.2016.02.002 spa
dc.identifier.issn 0946672X
dc.identifier.uri http://hdl.handle.net/11268/5037
dc.description.abstract Trace element bioavailability can play a role in several metabolic and physiological pathways known to be altered during the aging process. We aimed to explore the association of trace elements with increased lifespan by analyzing the circulating levels of seven trace elements (Cr, Cu, Fe, Mn, Mo, Se and Zn) in a cohort of healthy centenarians or ‘dodgers’ (≥100 years, free of major age-related diseases) in comparison with sex-matched younger elderly controls. Centenarians showed significant lower Cu (783.7 (76.7, 1608.9) vs 962.5 (676.3, 2064.4) μg/mL, P < 0.001), but higher Fe (1.3 (0.4, 4.7) vs 1.1 (0.5, 8.4) μg/mL, P = 0.003) and Se (85.7 (43.0, 256.7) vs 77.8 (24.3, 143.8) ng/mL, P = 0.002) values compared with elderly controls. The logistic regression analysis identified the combination of Cu and Se as significant predictor variables associated with successful aging (P = 0.001), while receiver operating characteristic (ROC) analysis confirmed that Cu and Se (either alone or in combination) were independent variables associated with healthy aging. An ‘improved’ trace element profile (reduced Cu and elevated Se, which are involved in key physiological processes) could play a role in the resistance to disease showed by centenarian ‘dodgers’, and, therefore, at least partly, be involved in the healthy aging phenotype shown by these subjects. These results should be confirmed in larger cohorts of other geographic/ethnic origin and the potential cause–effect association tested in mechanistic experimental settings. spa
dc.description.sponsorship PI15/00558 spa
dc.language.iso eng spa
dc.title Trace elements levels in centenarian ‘dodgers’ spa
dc.type article spa
dc.description.impact 3.225 JCR (2016) Q2, 65/138 Endocrinology and Metabolism, 118/290 Biochemistry and Molecular Biology spa
dc.identifier.doi 10.1016/j.jtemb.2016.02.002
dc.rights.accessRights openAccess spa
dc.subject.uem Geriatría spa
dc.subject.uem Anciano spa
dc.subject.unesco Gerontología spa
dc.subject.unesco Anciano spa
dc.description.filiation UEM spa
dc.peerreviewed Si spa


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