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Parasitostatic effect of maslinic acid. I. Growth arrest of Plasmodium falciparum intraerythrocytic stages

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dc.contributor.author Moneriz, Carlos
dc.contributor.author Marín-García, Patricia
dc.contributor.author García Granados, Andrés
dc.contributor.author Bautista, José M.
dc.contributor.author Díez, Amalia
dc.contributor.author Puyet, Antonio
dc.date.accessioned 2016-06-08T09:08:35Z
dc.date.available 2016-06-08T09:08:35Z
dc.date.issued 2011
dc.identifier.citation Moneriz, C., Marín-García, P., García-Granados, A., Bautista, J. M., Díez, A., & Puyet, A. (2011). Parasitostatic effect of maslinic acid. I. Growth arrest of Plasmodium falciparum intraerythrocytic stages. Malaria Journal, 10, 82. spa
dc.identifier.issn 14752875
dc.identifier.uri http://hdl.handle.net/11268/5210
dc.description.abstract Natural products have played an important role as leads for the development of new drugs against malaria. Recent studies have shown that maslinic acid (MA), a natural triterpene obtained from olive pomace, which displays multiple biological and antimicrobial activities, also exerts inhibitory effects on the development of some Apicomplexan, including Eimeria, Toxoplasma and Neospora. To ascertain if MA displays anti-malarial activity, the main objective of this study was to asses the effect of MA on Plasmodium falciparum-infected erythrocytes in vitro. Synchronized P. falciparum-infected erythrocyte cultures were incubated under different conditions with MA, and compared to chloroquine and atovaquone treated cultures. The effects on parasite growth were determined by monitoring the parasitaemia and the accumulation of the different infective stages visualized in thin blood smears. MA inhibits the growth of P. falciparum Dd2 and 3D7 strains in infected erythrocytes in, dose-dependent manner, leading to the accumulation of immature forms at IC50 concentrations, while higher doses produced non-viable parasite cells. MA-treated infected-erythrocyte cultures were compared to those treated with chloroquine or atovaquone, showing significant differences in the pattern of accumulation of parasitic stages. Transient MA treatment at different parasite stages showed that the compound targeted intra-erythrocytic processes from early-ring to schizont stage. These results indicate that MA has a parasitostatic effect, which does not inactivate permanently P. falciparum, as the removal of the compound allowed the infection to continue. MA displays anti-malarial activity at multiple intraerythrocytic stages of the parasite and, depending on the dose and incubation time, behaves as a plasmodial parasitostatic compound. This novel parasitostatic effect appears to be unrelated to previous mechanisms proposed for current anti-malarial drugs, and may be relevant to uncover new prospective plasmodial targets and opens novel possibilities of therapies associated to host immune response. spa
dc.description.sponsorship SIN FINANCIACIÓN spa
dc.language.iso eng spa
dc.rights Attribution 2.0 Generic *
dc.rights.uri http://creativecommons.org/licenses/by/2.0/ *
dc.title Parasitostatic effect of maslinic acid. I. Growth arrest of Plasmodium falciparum intraerythrocytic stages spa
dc.type article spa
dc.description.impact 3.191 JCR (2011) Q1, 7/34 Parasitology, 2/21 Tropical medicine spa
dc.identifier.doi 10.1186/1475-2875-10-82
dc.rights.accessRights openAccess spa
dc.subject.uem Malaria spa
dc.subject.unesco Malaria spa
dc.description.filiation UEM spa
dc.peerreviewed Si spa


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