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Levosimendan increases portal blood flow and attenuates intestinal intramucosal acidosis in experimental septic shock

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dc.contributor.author García Septiem, Javier
dc.contributor.author Lorente Balanza, José Ángel
dc.contributor.author Delgado Canto, Miguel Ángel
dc.contributor.author Paula, Marta de
dc.contributor.author Nin, Nicolás
dc.contributor.author Moscoso, Amelia
dc.contributor.author Sánchez Ferrer, A.
dc.contributor.author Pérez-Vizcaíno, Francisco
dc.contributor.author Esteban, Andrés
dc.date.accessioned 2016-07-01T13:57:55Z
dc.date.available 2016-07-01T13:57:55Z
dc.date.issued 2010
dc.identifier.citation García-Septien, J., Lorente, J. A., Delgado, M. A., de Paula, M., Nin, N., Moscoso, A., ... & Esteban, A. (2010). Levosimendan increases portal blood flow and attenuates intestinal intramucosal acidosis in experimental septic shock. Shock, 34(3), 275-280. spa
dc.identifier.issn 10732322
dc.identifier.uri http://hdl.handle.net/11268/5355
dc.description.abstract It has been proposed that vasodilatory therapy may increase microcirculatory blood flow and improve tissue oxygenation in septic shock. The authors aimed to evaluate the effects of levosimendan in systemic and splanchnic hemodynamics in a porcine model of septic shock in a randomized animal controlled study. This study was performed in an animal research facility in a university hospital. Anesthetized pigs were monitored with a pulmonary artery catheter and an ultrasonic blood flow probe in the portal vein for measurement of systemic and portal blood flows and with a tonometer placed in the small intestine for measurement of the intramucosal-arterial PCO2 gap. Three groups of pigs were studied: nonseptic (n = 7), septic (n = 7), and septic treated with levosimendan (n = 7). Levosimendan was administered i.v. at t = -10 min (200 microg/kg in i.v. bolus followed by 200 microg/kg per h). Sepsis was induced at t = 0 min by the administration of live Escherichia coli. Vascular reactivity was tested by the hemodynamic response to noradrenaline. Levosimendan markedly attenuated the sepsis-induced increase in pulmonary vascular resistance, decrease in portal/systemic blood flow, oliguria, impairment in oxygenation, hyperkalemia, and the widened intramucosal-arterial PCO2 gap. Systemic blood pressure and vascular resistance did not differ as compared with the septic untreated group. Responses to noradrenaline significantly improved in animals treated with levosimendan. Treatment with levosimendan in this animal model of sepsis attenuated pulmonary vasoconstriction and improved portal blood flow, intestinal mucosal oxygenation, pulmonary function, and vascular reactivity. spa
dc.description.sponsorship SIN FINANCIACIÓN spa
dc.language.iso eng spa
dc.title Levosimendan increases portal blood flow and attenuates intestinal intramucosal acidosis in experimental septic shock spa
dc.type article spa
dc.description.impact 3.203 JCR (2010) Q1, 16/68 Peripheral vascular diasease, 20/188 Surgery; Q2, 25/66 Hematology, 7/23 Critical care medicine spa
dc.identifier.doi 10.1097/SHK.0b013e3181cd8c5b
dc.rights.accessRights closedAccess spa
dc.subject.uem Bacteriemia spa
dc.subject.unesco Enfermedad cardiovascular spa
dc.description.filiation UEM spa
dc.peerreviewed Si spa


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