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ACTN3 genotype in professional endurance cyclists

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dc.contributor.author Lucía Mulas, Alejandro
dc.contributor.author Gómez Gallego, Félix
dc.contributor.author Santiago Dorrego, Catalina
dc.contributor.author Bandrés Moya, Fernando
dc.contributor.author Earnest, C. P.
dc.contributor.author Rabadán, Manuel
dc.contributor.author Alonso, Juan Manuel
dc.contributor.author Hoyos, J.
dc.contributor.author Córdova, Alfredo
dc.contributor.author Villa Vicente, José Gerardo
dc.contributor.author Foster, Carl
dc.date.accessioned 2016-07-28T16:39:10Z
dc.date.available 2016-07-28T16:39:10Z
dc.date.issued 2006
dc.identifier.citation Lucía, A., Gómez-Gallego, F., Santiago, C., Bandrés, F., Earnest, C., Rabadán, M., ...& Foster, C. (2006). ACTN3 genotype in professional endurance cyclists. International journal of sports medicine, 27(11), 880-884. spa
dc.identifier.issn 01724622
dc.identifier.issn 14393964
dc.identifier.uri http://hdl.handle.net/11268/5514
dc.description.abstract The Z-disk protein alpha-actinin-3 is only expressed in type II muscle fibres, which are responsible for generating forceful contractions at high velocity. Despite the evolutionary conservation of alpha-actinin-3, approximately one in every five Caucasians of European ancestry is totally deficient in this protein, due to homozygosity for a R577X polymorphism in the ACTN3 gene. This, together with the results of recent research on elite athletes, suggests that the "null" XX polymorphism might confer some advantage to endurance performance events. To test this hypothesis, we studied the frequency distribution of R577X genotypes in a group of 50 top-level male professional cyclists (26.9 +/- 0.4 yrs [mean +/- SEM]; VO2max: 73.5 +/- 0.8 ml x kg (-1) x min (-1)). Their results were compared with those of a group of 52 Olympic-class male endurance runners (26.8 +/- 0.6 yrs; VO2max: 73.3 +/- 0.8 ml x kg (-1) x min (-1)) and 123 healthy, sedentary male controls. All subjects were Caucasian, and of European ancestry. No significant differences (p > 0.05) were found between groups: RR: 28.5 %; RX: 53.6 % and XX: 17.9 % in controls; RR: 28.0 %; RX: 46.0 % and XX: 26.0 % in cyclists; and RR: 25.0 %; RX: 57.7 %; XX: 17.3 % in runners). No differences were found in indices of endurance performance (VO2peak or ventilatory thresholds) between athlete carriers of each R577X genotype. In summary, although the alpha-actinin-3 deficient XX genotype may be detrimental for sprint performance in humans, the R577X polymorphism of the ACTN3 gene does not appear to confer an advantage on the ability of male athletes to sustain extreme endurance performance. spa
dc.description.sponsorship SIN FINANCIACIÓN spa
dc.language.iso eng spa
dc.title ACTN3 genotype in professional endurance cyclists spa
dc.type article spa
dc.description.impact 0.685 SJR (2006) Q2, 42/153 Orthopedics and sports medicine, 36/91 Sports science spa
dc.identifier.doi 10.1055/s-2006-92386
dc.rights.accessRights closedAccess spa
dc.subject.uem Genética humana spa
dc.subject.uem Ciclismo spa
dc.subject.unesco Medicina deportiva spa
dc.description.filiation UEM spa
dc.peerreviewed Si spa


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