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Choline kinase is a novel oncogene that potentiates RhoA-induced carcinogenesis

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dc.contributor.author Ramírez de Molina, Ana
dc.contributor.author Gallego-Ortega, David
dc.contributor.author Sarmentero, Jacinto
dc.contributor.author Bañez-Coronel, Mónica
dc.contributor.author Martín Cantalejo, Yolanda
dc.contributor.author Lacal, Juan Carlos
dc.date.accessioned 2016-08-03T08:43:39Z
dc.date.available 2016-08-03T08:43:39Z
dc.date.issued 2005
dc.identifier.citation Ramírez de Molina, A., Gallego-Ortega, D., Sarmentero, J., Bañez-Coronel, M., Martín-Cantalejo, Y., & Lacal, J. C. (2005). Choline kinase is a novel oncogene that potentiates RhoA-induced carcinogenesis. Cancer Research, 65(13), 5647-5653. spa
dc.identifier.issn 00085472
dc.identifier.issn 15387445
dc.identifier.uri http://hdl.handle.net/11268/5533
dc.description.abstract Choline kinase is overexpressed in human breast, lung, colorectal, and prostate tumors, a finding that suggests the involvement of this enzyme in carcinogenesis. Here we show that overexpression of choline kinase induce oncogenic transformation of human embryo kidney fibroblasts and canine epithelial Madin-Darby canine kidney cells. Choline kinase lays downstream of RhoA signaling and is activated through ROCK kinase, one of the best-characterized RhoA effectors. In keeping with this, coexpression of RhoA and choline kinase potentiates both anchorage independent growth and tumorigenesis. Finally, choline kinase–mediated transformation is sensitive to MN58b, a well-characterized specific choline kinase inhibitor. These results provide the definitive evidence that choline kinase has oncogenic properties and that choline kinase inhibition constitutes a novel valid antitumor strategy. spa
dc.description.sponsorship SAF2001-2042 spa
dc.description.sponsorship FIS C03-08 spa
dc.description.sponsorship FIS C03-10 spa
dc.language.iso eng spa
dc.title Choline kinase is a novel oncogene that potentiates RhoA-induced carcinogenesis spa
dc.type article spa
dc.description.impact 7.616 JCR (2005) Q1, 11/123 Oncology spa
dc.identifier.doi 10.1158/0008-5472.CAN-04-4416
dc.rights.accessRights openAccess spa
dc.subject.uem Oncología spa
dc.subject.unesco Cáncer spa
dc.description.filiation UEM spa
dc.relation.publisherversion http://cancerres.aacrjournals.org/content/65/13/5647. full spa
dc.peerreviewed Si spa


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