mirage

Endotoxin decreases serum IGFBP-3 and liver IGFBP-3 mRNA: Comparison between Lewis and Wistar rats

ABACUS/Manakin Repository

Show simple item record

dc.contributor.author Priego, Teresa
dc.contributor.author Ibáñez de Cáceres, Inmaculada
dc.contributor.author Martín, Ana Isabel
dc.contributor.author Villanúa, María de los Ángeles
dc.contributor.author López-Calderón, Asunción
dc.date.accessioned 2016-08-25T09:41:46Z
dc.date.available 2016-08-25T09:41:46Z
dc.date.issued 2003
dc.identifier.citation Priego, T., Ibáñez de Cáceres, I., Martín, A. I., Villanúa, M. A., & López-Calderón, A. (2003). Endotoxin decreases serum IGFBP-3 and liver IGFBP-3 mRNA: Comparison between Lewis and Wistar rats. Molecular and Cellular Endocrinology, 199(1-2), 23-28. spa
dc.identifier.issn 03037207
dc.identifier.uri http://hdl.handle.net/11268/5679
dc.description.abstract We studied the IGFBP-3 response to endotoxin, in Wistar and Lewis rats. Compared to Wistar rats, Lewis rats have a reduced adrenal and IGF-I response to inflammatory stimuli. Rats received two injections of 1 mg/kg of lipopolysaccharide (LPS) and were killed 4 h after the second injection. LPS decreased serum concentrations of GH in Wistar (P<0.05), but not in Lewis rats. However, serum IGFBP-3 was decreased both in Wistar and in Lewis rats. Furthermore, LPS administration decreased IGFBP-3 gene expression in the liver in both rat strains (P<0.01). Lewis rats had lower serum IGFBP-3 than Wistar rats (P<0.01). This difference could be secondary to the increased IGFBP-3 proteolysis in serum observed in Lewis rats. These data indicate that acute inflammation inhibits serum concentrations of IGFBP-3 by decreasing its synthesis in the liver, rather than increasing its proteolysis. This effect seems to be GH and IGF-I independent. spa
dc.description.sponsorship SIN FINANCIACIÓN spa
dc.language.iso eng spa
dc.title Endotoxin decreases serum IGFBP-3 and liver IGFBP-3 mRNA: Comparison between Lewis and Wistar rats spa
dc.type article spa
dc.description.impact 2.637 JCR (2003) Q2, 68/156 Cell biology, 37/88 endocrinology & metabolism spa
dc.identifier.doi 10.1016/S0303-7207(02)00356-8
dc.rights.accessRights closedAccess spa
dc.subject.uem Endocrinología spa
dc.subject.uem Metabolismo spa
dc.subject.uem Biología humana spa
dc.subject.unesco Sistema endocrino spa
dc.subject.unesco Biología celular spa
dc.description.filiation UEM spa
dc.peerreviewed Si spa


Files in this item

Files Size Format View

There are no files associated with this item.

This item appears in the following Collection(s)

Show simple item record