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Effect of inducible nitric oxide synthase inhibition by aminoguanidine on insulin-like growth factor binding protein-3 in adjuvant-induced arthritic rats

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dc.contributor.author Ibáñez de Cáceres, Inmaculada
dc.contributor.author Priego, Teresa
dc.contributor.author Martín Velasco, Ana Isabel
dc.contributor.author Granado, Miriam
dc.contributor.author López-Calderón, Asunción
dc.contributor.author Villanúa, María de los Ángeles
dc.date.accessioned 2016-08-25T09:48:29Z
dc.date.available 2016-08-25T09:48:29Z
dc.date.issued 2003
dc.identifier.citation Íbañez de Cáceres, I., Priego, T., Martín Velasco, A. I., Granado, M., López-Calderón, A., & Villanúa, M. A. (2003). Effect of inducible nitric oxide synthase inhibition by aminoguanidine on insulin-like growth factor binding protein-3 in adjuvant-induced arthritic rats. European Journal of Pharmacology, 481(2-3), 293-299. spa
dc.identifier.issn 00142999
dc.identifier.uri http://hdl.handle.net/11268/5681
dc.description.abstract This study was designed to investigate whether nitric oxide (NO) mediates changes in insulin-like growth factor binding protein-3 (IGFBP-3) levels in rats with adjuvant-induced arthritis. Male Wistar rats were injected with complete Freund's adjuvant, and 20 days afterwards arthritic and control rats were injected daily with an inhibitor of inducible NO synthase (iNOS), aminoguanidine, or vehicle for 8 days. The increase in serum levels of IGFBP-3 induced by arthritis was exacerbated by aminoguanidine treatment. Arthritis increased IGFBP-3 mRNA levels in the kidney but not in the liver. The inhibition of iNOS did not modify IGFBP-3 gene expression in the kidney or in the liver in arthritic rats. However, the inhibitory effect of arthritis on the proteolysis of IGFBP-3 in serum was potentiated by aminoguanidine administration. These results indicate that arthritis increases serum IGFBP-3 by increasing its synthesis in the kidney and decreasing its proteolysis in serum and that these effects are not mediated by NO. spa
dc.description.sponsorship SIN FINANCIACIÓN spa
dc.language.iso eng spa
dc.title Effect of inducible nitric oxide synthase inhibition by aminoguanidine on insulin-like growth factor binding protein-3 in adjuvant-induced arthritic rats spa
dc.type article spa
dc.description.impact 2.352 JCR (2003) Q2, 56/185 Pharmacology & pharmacy spa
dc.identifier.doi 10.1016/j.ejphar.2003.09.038
dc.rights.accessRights closedAccess spa
dc.subject.uem Artritis spa
dc.subject.uem Insulina spa
dc.subject.uem Farmacia spa
dc.subject.unesco Farmacología spa
dc.description.filiation UEM spa
dc.peerreviewed Si spa


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