GH administration and renal IGF-I system in arthritic rats

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dc.contributor.author Ibáñez de Cáceres, Inmaculada
dc.contributor.author Priego, Teresa
dc.contributor.author Martín Velasco, Ana Isabel
dc.contributor.author López-Calderón, Asunción
dc.contributor.author Villanúa, María de los Ángeles
dc.date.accessioned 2016-09-06T09:00:34Z
dc.date.available 2016-09-06T09:00:34Z
dc.date.issued 2002
dc.identifier.citation Ibáñez de Cáceres, I., Priego, T., Martín Velasco, A. I., López-Calderón, A., & Villanúa, M. A. (2002). GH administration and renal IGF-I system in arthritic rats. Life Sciences, 71(2), 139-151. spa
dc.identifier.issn 00243205
dc.identifier.uri http://hdl.handle.net/11268/5706
dc.description.abstract Experimental arthritis in rats results in a growth failure and a decrease in circulating and hepatic concentrations of insulin-like growth factor I (IGF-I). Renal damage has also been reported in arthritic rats. The aim of this study was 1) to analyse if alterations in the IGF-I system in the kidney occurs in adjuvant-induced arthritis and 2) to analyse if recombinant human GH (rhGH) administration is able to reverse these effects. Male Wistar rats were injected with complete Freund's adjuvant or vehicle and 22 days later they were killed. Arthritis increased serum creatinine levels, relative kidney weight and IGF-I concentrations in this organ. In a second experiment, arthritic and control rats received rhGH (3 UI/Kg sc) or 250 μl saline from day 14, after adjuvant or vehicle injection, until day 22. IGF-I concentrations were higher in both the renal cortex and medulla of arthritic rats. In contrast, kidney IGF-I mRNA was lower in both areas of arthritic animals. GH treatment significantly decreased serum creatinine levels and IGF-I concentrations in the kidney cortex and medulla of arthritic rats. However, the administration of rhGH to arthritic animals significantly increased the IGF-I gene expression in both the renal cortex and medulla. Serum and kidney concentrations of IGF-I binding proteins (IGFBPs) were increased in arthritic animals and they were reduced by GH administration. Conclusion: These data suggest that experimental arthritis causes renal dysfunction and GH treatment can ameliorate this effect. spa
dc.description.sponsorship SIN FINANCIACIÓN spa
dc.language.iso eng spa
dc.title GH administration and renal IGF-I system in arthritic rats spa
dc.type article spa
dc.description.impact 1.824 JCR (2002) Q2, 33/74 Medicine, research & experimental, 74/188 Pharmacology & pharmacy spa
dc.identifier.doi 10.1016/S0024-3205(02)01640-5
dc.rights.accessRights closedAccess spa
dc.subject.uem Artritis spa
dc.subject.uem Farmacología spa
dc.subject.uem Proteínas spa
dc.subject.unesco Farmacología spa
dc.subject.unesco Proteína spa
dc.description.filiation UEM spa
dc.peerreviewed Si spa

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