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Effects of an endurance cycling competition on resting serum insulin-like growth factor I (IGF-I) and its binding proteins IGFBP-1 and IGFBP-3  

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dc.contributor.author López Chicharro, José
dc.contributor.author López-Calderón, Asunción
dc.contributor.author Hoyos, J.
dc.contributor.author Martín Velasco, Ana Isabel
dc.contributor.author Villa Vicente, José Gerardo
dc.contributor.author Villanúa, María de los Ángeles
dc.contributor.author Lucía Mulas, Alejandro
dc.date.accessioned 2016-09-13T15:42:49Z
dc.date.available 2016-09-13T15:42:49Z
dc.date.issued 2001
dc.identifier.citation López Chicharro, J., López-Calderón, A., Hoyos, J., Martín-Velasco, A. I., Villa, G., Villanúa, M. A., & Lucía Mulas, A. (2001). Effects of an endurance cycling competition on resting serum insulin-like growth factor I (IGF-I) and its binding proteins IGFBP-1 and IGFBP-3. British Journal of Sports Medicine, 35(5), 303-307. DOI: 10.1136/bjsm.35.5.303 spa
dc.identifier.issn 03063674
dc.identifier.issn 14730480
dc.identifier.uri http://hdl.handle.net/11268/5754
dc.description.abstract The aim of this study is to determine whether consecutive bouts of intense endurance exercise over a three week period alters serum concentrations of insulin-like growth factor I (IGF-I) and/or its binding proteins. Seventeen professional cyclists (mean (SEM) VO2MAX, 74.7 (2.1) ml/kg/min; age, 27 (1) years) competing in a three week tour race were selected as subjects. Blood samples were collected at each of the following time points: t0 (control, before the start of competition), t1 (end of first week), and t3 (end of third week). Serum levels of both total and free IGF-I and IGF binding proteins 1 and 3 (IGFBP-1 and IGFBP-3) were measured in each of the samples. Cortisol levels were measured in nine subjects. A significant (p<0.01) increase was found in total IGF-I and IGFBP-1 at both t1 and t3 compared with t0 (IGF-I: 110.9 (17.7), 186.8 (12.0), 196.9 (14.7) ng/ml at t0, t1, and t3 respectively; IGFBP-1: 54.6 (6.6), 80.6 (8.0), and 89.2 (7.9) ng/ml at t0, t1, and t3 respectively). A significant (p<0.01) decrease was noted in free IGF-I at t3 compared with both t0 and t1 (t0: 0.9 (0.1) ng/ml; t1: 0.9 (0.1) ng/ml; t3: 0.7 (0.1) ng/ml); in contrast, IGFBP-3 levels remained stable throughout the race. It would appear that the increase in circulating levels of both IGF-I and its binding protein IGFBP-1 is a short term (one week) endocrine adaptation to endurance exercise. After three weeks of training, total IGF-I and IGFBP-1 remained stable, whereas free IGF-I fell below starting levels. spa
dc.description.sponsorship Asociación Deportiva Banesto spa
dc.language.iso eng spa
dc.title Effects of an endurance cycling competition on resting serum insulin-like growth factor I (IGF-I) and its binding proteins IGFBP-1 and IGFBP-3   spa
dc.type article spa
dc.description.impact 1.032 JCR (2001) Q2, 21/68 Sport sciences spa
dc.identifier.doi 10.1136/bjsm.35.5.303
dc.rights.accessRights openAccess spa
dc.subject.uem Proteínas spa
dc.subject.uem Insulina spa
dc.subject.uem Medicina deportiva spa
dc.subject.unesco Medicina deportiva spa
dc.subject.unesco Proteína spa
dc.description.filiation UEM spa
dc.peerreviewed Si spa


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