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Patterns of GABABR1a,b receptor gene expression in monkey and human visual cortex

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dc.contributor.author Múñoz, Alberto Eduardo
dc.contributor.author DeFelipe, Javier
dc.contributor.author Jones, Edward G.
dc.date.accessioned 2016-09-15T16:54:54Z
dc.date.available 2016-09-15T16:54:54Z
dc.date.issued 2001
dc.identifier.citation Múñoz, A. E., DeFelipe, J., & Jones, E. G. (2001). Patterns of GABABR1a,b receptor gene expression in monkey and human visual cortex. Cerebral Cortex, 11(2), 104-113. spa
dc.identifier.issn 10473211
dc.identifier.uri http://hdl.handle.net/11268/5758
dc.description.abstract In situ hybridization histochemistry and immunocytochemistry were used to examine GABABR1a,b receptor mRNA and protein expression in areas 17 and 18 of the visual cortex of normal macaque monkeys and of monkeys that had been deprived of vision in one eye. In addition, the normal patterns of GABABR1a,b protein expression were immunocytochemically studied in the human visual cortex. Overall levels of GABABR1a,b transcript were higher in area 17 than in area 18. In area 17 GABABR1a,b mRNA levels were highest in layers IVC and VI, moderate in layers II-IVA and low in layers I, IVB and V. In area 18 GABABR1a,b transcript expression was high in layers II and III, moderate in layers IV and VI and low in layers I and V. Immunocytochemistry revealed nearly identical patterns of GABABR1a,b protein expression in areas 17 and 18 in monkey and human. Both pyramidal and non-pyramidal neurons were GABABR1a,b immunoreactive. The majority of intensely immunoreactive neurons in layers II, III, V and VI were pyramidal cells. Numerous non-pyramidal cells were intensely immunoreactive in layer IV of area 17 but layer IV cells were only lightly immunoreactive in area 18. Following 10 day periods of monocular deprivation, induced by intravitreal injections of tetrodotoxin, levels of GABABR1a,b mRNA and protein were decreased in the deprived eye dominance columns of layers IVC and VI. spa
dc.description.sponsorship SIN FINANCIACIÓN spa
dc.language.iso eng spa
dc.title Patterns of GABABR1a,b receptor gene expression in monkey and human visual cortex spa
dc.type article spa
dc.description.impact 6.578 JCR (2001) Q1, 18/198 Neurosciences spa
dc.rights.accessRights closedAccess spa
dc.subject.uem Neurociencia spa
dc.subject.uem Fisiología spa
dc.subject.unesco Neurología spa
dc.subject.unesco Fisiología spa
dc.description.filiation UEM spa
dc.peerreviewed Si spa


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