New bioactive semisynthetic derivatives of 31-norlanosterol and obtusifoliol from Euphorbia officinarum

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dc.contributor.author Bailén Andrino, María
dc.contributor.author Khamlichi, M. D.
dc.contributor.author Benharref, A.
dc.contributor.author Martínez-Díaz, Rafael A.
dc.contributor.author González-Coloma, Azucena
dc.date.accessioned 2016-10-13T11:58:21Z
dc.date.available 2016-10-13T11:58:21Z
dc.date.issued 2016
dc.identifier.citation Bailen, M., Khamlichi, M. D., Benharref, A., Martinez-Diaz, R. A., & Gonzalez-Coloma, A. (2016). New Bioactive Semisynthetic Derivatives of 31-Norlanostenol and Obtusifoliol from Euphorbia officinarum. Natural product communications, 11(6), 733-738. spa
dc.identifier.issn 1934578X
dc.identifier.uri http://hdl.handle.net/11268/5869
dc.description.abstract Fifteen semisynthetic terpenoid derivatives from the major latex components of Euphorbia officinarum have been evaluated against the insect pest Spodoptera littoralis, two species of protozoan parasites, Trypanosoma cruzi and Leishmania infantum, and also against insect Sf9 and mammalian CHO cells to test their selective cytotoxicity. Our results showed that 40% of the test substances were postingestive toxicants to S. littoralis. All the tested derivatives had cytotoxic effects on insect-derived Sf9 cells, whereas mammalian CHO cells were affected by a lower number of compounds (47%). Furthermore, 87% of the test compounds had antiparasitic effects on both L. infantum and T. cruzi, with some of them being selective parasite toxicants. spa
dc.description.sponsorship Sin financiación spa
dc.language.iso eng spa
dc.title New bioactive semisynthetic derivatives of 31-norlanosterol and obtusifoliol from Euphorbia officinarum spa
dc.type article spa
dc.description.impact 0.773 JCR (2016) Q4, 98/130 Food Science and Technology, 56/60 Chemistry, Medical spa
dc.rights.accessRights closedAccess spa
dc.subject.uem Euforbiáceas spa
dc.subject.uem Compuestos orgánicos - Síntesis spa
dc.subject.unesco Recursos vegetales spa
dc.subject.unesco Ciencias químicas spa
dc.description.filiation UEM spa
dc.peerreviewed Si spa

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