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Evolution of antibiotic multiresistance in Escherichia coli and Klebsiella pneumoniae isolates from blood cultures. A 15-year analysis (2000-2014)

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dc.contributor.author Molina Arana, David
dc.contributor.author Rubio Alonso, Margarita
dc.contributor.author Alós Cortés, Juan Ignacio
dc.date.accessioned 2016-10-13T12:31:59Z
dc.date.available 2016-10-13T12:31:59Z
dc.date.issued 2016
dc.identifier.citation Arana, D. M., Rubio, M., & Alós, J. I. (2017). Evolution of antibiotic multiresistance in Escherichia coli and Klebsiella pneumoniae isolates from urinary tract infections: A 12-year analysis (2003–2014). Enfermedades infecciosas y microbiologia clinica, 35(5), 293-298. spa
dc.identifier.uri http://hdl.handle.net/11268/5870
dc.description.abstract The aim of this study was to identify multi-drug resistance (MDR) in the main enterobacteriaceae implicated in urinary tract infections (Escherichia coli and Klebsiella pneumoniae) from both, community and hospitalized patients and to analyze the evolution over a 12-year period. Microb Dynamic software was used to analyze the microbiology laboratory database and a chi square test was applied to compare differences in group proportions and to determine the linear trend over 12 years in three different periods: 2003-2006, 2007-2010, 2011-2014. We chose amoxicillin, gentamicin, ciprofloxacin and trimethoprim-sulphamethoxazole as MDR markers. A total of 39,980 positive urine samples were analyzed, 34,564 (3786 from hospitalized patients and 30,778 from non-hospitalized patients) E. coli isolates, and 5,422 (774 from hospitalized patients and 4,648 from non-hospitalized patients) K. pneumoniae isolates. The prevalence of UTI due to MDR E. coli and MDR K. pneumoniae significantly increased in the period studied, both in hospitalized and outpatients. A higher percentage of MDR E. coli (5.89% in 2007-2010 versus 8.18% in 2011-2014) and MDR K. pneumoniae (2.38% in 2007-2010 versus 9.35% in 2011-2014) was evident and maintained constant over time in hospitalized patients in comparison to non-hospitalized ones. Infection due to MDR ESBL-producing E. coli and K. pneumoniae increased significantly during the last 8 years in both, hospitalized (20% versus 38% and 66.8% versus 82.6%, respectively) and non-hospitalized patients (18.2% versus 23.6% and 51% versus 74.6%, respectively). This study includes data of a large sample size of urinary strains isolated over a 12 year period and demonstrates that MDR is an increasing phenomenon of particular importance in the main UTI-causing species. spa
dc.description.sponsorship SIN FINANCIACIÓN spa
dc.language.iso eng spa
dc.title Evolution of antibiotic multiresistance in Escherichia coli and Klebsiella pneumoniae isolates from blood cultures. A 15-year analysis (2000-2014) spa
dc.title.alternative Evolución de la multirresistencia a los antibióticos en Escherichia coli y Klebsiella pneumoniae aislados de infecciones del tracto urinario. Un análisis de 12 años (2003-2014) spa
dc.type article spa
dc.description.impact 0.434 SJR (2016) Q3, 69/118 Microbiology (Medical) spa
dc.identifier.doi 10.1016/j.eimc.2016.02.018
dc.rights.accessRights closedAccess spa
dc.subject.uem Resistencia a los antibióticos spa
dc.subject.uem Aparato urinario - Infecciones spa
dc.subject.unesco Medicina clínica spa
dc.description.filiation UEM spa
dc.peerreviewed Si spa


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