Mitochondrially Targeted Nanoparticles Based on α-TOS for the Selective Cancer Treatment

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dc.contributor.author Palao Suay, Raquel
dc.contributor.author Rodríguañez, Laura
dc.contributor.author Aguilar de Armas, María Rosa
dc.contributor.author Sánchez Rodríguez, Carolina
dc.contributor.author Parra Ruiz, F. J.
dc.contributor.author Fernández Gutiérrez, M.
dc.contributor.author Parra, J.
dc.contributor.author Riestra Ayora, Juan Ignacio
dc.contributor.author Sanz Fernández, Ricardo
dc.contributor.author Román, J. S.
dc.date.accessioned 2016-10-29T18:26:17Z
dc.date.available 2016-10-29T18:26:17Z
dc.date.issued 2016
dc.identifier.citation Palao‐Suay, R., Rodrigáñez, L., Aguilar, M. R., Sánchez‐Rodríguez, C., Parra, F., Fernández, M., ... & Román, J. S. (2016). Mitochondrially Targeted Nanoparticles Based on α‐TOS for the Selective Cancer Treatment. Macromolecular bioscience, 16 (3), 395-411. DOI: 10.1002/mabi.201500265 spa
dc.identifier.issn 1616-5187
dc.identifier.uri http://hdl.handle.net/11268/5935
dc.description.abstract The aim of this work is the preparation of an active nanovehicle for the effective administration of α-tocopheryl succinate (α-TOS). α-TOS is loaded in the core of nanoparticles (NPs) based on amphiphilic pseudo-block copolymers of N-vinyl pyrrolidone and a methacrylic derivative of α-TOS. These well-defi ned spherical NPs have sizes below 165 nm and high encapsulation effi - ciencies. In vitro activity of NPs is tested in hypopharynx squamous carcinoma (FaDu) cells and nonmalignant epithelial cells, demonstrating that the presence of additional α-TOS signifi cantly enhances its antiproliferative activity; however, a range of selective concentrations is observed. These NPs induce apoptosis of FaDu cells by activating the mitochondria death pathway (via caspase-9). Both loaded and unloaded NPs act via complex II and produce high levels of reactive oxygen species that trigger apoptosis. Additionally, these NPs effectively suppress the vascular endothelial growth factor (VEGF) expression of human umbilical vein endothelial cells (HUVECs). These results open the possibility to use this promising nanoformulation as an α-TOS delivery system for the effective cancer treatment, effectively resolving the current limitations of free α-TOS administration. spa
dc.description.sponsorship Ministerio de Economía y Competitividad MAT2010-18155; Proyecto Fundación CIBER BBN-ECO; Universidad Europea de Madrid spa
dc.language.iso eng spa
dc.title Mitochondrially Targeted Nanoparticles Based on α-TOS for the Selective Cancer Treatment spa
dc.type article spa
dc.description.impact 3.238 JCR (2016) Q1, 17/86 Polymer Science; Q2, 112/290 Biochemistry and Mollecular Biology, 13/33 Materials Science, Biomaterials spa
dc.identifier.doi 10.1002/mabi.201500265
dc.relation.projectID Grant Number: MAT2010-18155 spa
dc.rights.accessRights closedAccess spa
dc.subject.uem Polímeros spa
dc.subject.uem Salud spa
dc.subject.unesco Polímero spa
dc.subject.unesco Salud spa
dc.description.filiation UEM spa
dc.peerreviewed Si spa

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