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Chronic inflammation inhibits GH secretion and alters the serum insulin-like growth factor system in rats

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dc.contributor.author López-Calderón, Asunción
dc.contributor.author Soto, Luis J.
dc.contributor.author Martín Velasco, Ana Isabel
dc.date.accessioned 2016-11-26T17:19:10Z
dc.date.available 2016-11-26T17:19:10Z
dc.date.issued 1999
dc.identifier.citation López-Calderón, A., Soto, L., y Martín, A. I. (1999). Chronic inflammation inhibits GH secretion and alters the serum insulin-like growth factor system in rats. Life sciences, 65(20), 2049-2060. spa
dc.identifier.issn 00243205
dc.identifier.uri http://hdl.handle.net/11268/6013
dc.description.abstract Adjuvant-induced arthritis in rats is associated with growth failure, hypermetabolism and accelerated protein breakdown. The aim of this work was to study the effects of adjuvant-induced arthritis on GH and insulin-like growth factor-I (IGF-I). Arthritis was induced by an intradermal injection of complete Freund's adjuvant and rats were killed 18 and 22 days later. IGF-I and GH levels were measured by radioimmunoassay. Pituitary GH mRNA was analyzed by northern blot and IGF binding proteins (IGFBPs) by western blot. Arthritic rats showed a decrease in both serum and hepatic concentrations of IGF-I. On the contrary, arthritis increased the circulating IGFBPs. The serum concentration of IGF-I in the arthritic rats was negatively correlated with the body weight loss observed in these animals. Arthritis decreased the serum concentration of GH and this decrease seems to be due to an inhibition of GH synthesis, since pituitary GH mRNA content was decreased in arthritic rats (p<0.01). These data suggest that the decrease in body weight gain in arthritic rats may be, at least in part, secondary to the decrease in GH and IGF-I secretion. Furthermore, the increased serum IGFBPs may also be involved in the disease process. spa
dc.description.sponsorship Sin financiación spa
dc.language.iso eng spa
dc.subject.other Hormona spa
dc.title Chronic inflammation inhibits GH secretion and alters the serum insulin-like growth factor system in rats spa
dc.type article spa
dc.description.impact 1.774 JCR (1999) Q2, 27/76 Medicine, Research and Experimental, 58/175 Pharmacology and Pharmacy, 16/53 Biology spa
dc.identifier.doi 10.1016/S0024-3205(99)00472-5
dc.rights.accessRights closedAccess spa
dc.subject.uem Fisiología humana spa
dc.subject.uem Artitris spa
dc.subject.uem Insulina spa
dc.subject.unesco Efectos fisiológicos spa
dc.subject.unesco Farmacología spa
dc.description.filiation UEM spa
dc.peerreviewed Si spa


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