Altered oscillatory dynamics of CA1 parvalbumin-basket cells during theta-gamma rhythmopathies of temporal lobe epilepsy

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dc.contributor.author López Pigozzi, Diego
dc.contributor.author Laurent, François
dc.contributor.author Brotons-Mas, Jorge
dc.contributor.author Valderrama, Mario
dc.contributor.author Valero, Manuel
dc.contributor.author Frenández Lamo, Iván
dc.contributor.author Gómez-Domínguez, Daniel
dc.contributor.author Menéndez de la Prida, Liset
dc.contributor.author Cid, Elena
dc.contributor.author Gal Iglesias, Beatriz
dc.contributor.author Menéndez de la Prida, Liset
dc.date.accessioned 2016-12-20T10:42:29Z
dc.date.available 2016-12-20T10:42:29Z
dc.date.issued 2016
dc.identifier.citation López-Pigozzi, D., Laurent, F., Brotons-Mas, J. R., Valderrama, M., Valero, M., Fernández-Lamo, I., ... & de la Prida, L. M. (2016). Altered Oscillatory Dynamics of CA1 Parvalbumin Basket Cells during Theta–Gamma Rhythmopathies of Temporal Lobe Epilepsy. eNeuro, 3(6). DOI: 10.1523/ENEURO.0284-16.2016 spa
dc.identifier.issn 23732822
dc.identifier.uri http://hdl.handle.net/11268/6115
dc.description.abstract Recent reports in human demonstrate a role of theta– gamma coupling in memory for spatial episodes and a lack of coupling in people experiencing temporal lobe epilepsy, but the mechanisms are unknown. Using multisite silicon probe recordings of epileptic rats engaged in episodic-like object recognition tasks, we sought to evaluate the role of theta– gamma coupling in the absence of epileptiform activities. Our data reveal a specific association between theta– gamma (30 – 60 Hz) coupling at the proximal stratum radiatum of CA1 and spatial memory deficits. We targeted the microcircuit mechanisms with a novel approach to identify putative interneuronal types in tetrode recordings (parvalbumin basket cells in particular) and validated classification criteria in the epileptic context with neurochemical identification of intracellularly recorded cells. In epileptic rats, putative parvalbumin basket cells fired poorly modulated at the falling theta phase, consistent with weaker inputs from Schaffer collaterals and attenuated gamma oscillations, as evaluated by theta-phase decomposition of current–source density signals. We propose that theta– gamma interneuronal rhythmopathies of the temporal lobe are intimately related to episodic memory dysfunction in this condition. spa
dc.description.sponsorship BFU2012-37156-C03-01 spa
dc.language.iso eng spa
dc.title Altered oscillatory dynamics of CA1 parvalbumin-basket cells during theta-gamma rhythmopathies of temporal lobe epilepsy spa
dc.type article spa
dc.description.impact 0.456 SJR (2016) Q2, 668/1806 Medicine (miscellaneous); Q3, 85/136 Neuroscience (miscellaneous) spa
dc.identifier.doi 10.1523/ENEURO.0284-16.2016
dc.rights.accessRights closedAccess spa
dc.subject.uem Neurociencias spa
dc.subject.uem Epilepsia spa
dc.subject.unesco Investigación sobre el cerebro spa
dc.subject.unesco Neurología spa
dc.description.filiation UEM spa
dc.peerreviewed Si spa

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