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Characteristics of microRNAs and their potential relevance for the diagnosis and therapy of the acute respiratory distress syndrome: from bench to bedside

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dc.contributor.author Cardinal Fernández, Pablo
dc.contributor.author Ferruelo, A.
dc.contributor.author Esteban, Andrés
dc.contributor.author Lorente Balanza, José Ángel
dc.date.accessioned 2016-12-22T16:09:28Z
dc.date.available 2016-12-22T16:09:28Z
dc.date.issued 2016
dc.identifier.citation Cardinal-Fernández, P., Ferruelo, A., Esteban, A., & Lorente, J. A. (2016). Characteristics of microRNAs and their potential relevance for the diagnosis and therapy of the acute respiratory distress syndrome: from bench to bedside. Translational Research, 169, 102-111. DOI: 10.1016/j.trsl.2015.11.004 spa
dc.identifier.issn 19315244
dc.identifier.uri http://hdl.handle.net/11268/6124
dc.description.abstract Acute respiratory distress syndrome (ARDS) is a complex disease associated with high morbidity and mortality. Biomarkers and specific pharmacologic treatment of the syndrome are lacking. MicroRNAs (miRNAs) are small (∼19–22 nucleotides) noncoding RNA molecules whose function is the regulation of gene expression. Their uncommon biochemical characteristics (eg, their resistance to degradation because of extreme temperature and pH fluctuations, freeze-thaw cycles, long storage times in frozen conditions, and RNAse digestion) and their presence in a wide range of different biological fluids and the relatively low number of individual miRNAs make these molecules good biomarkers in different clinical conditions. In addition, miRNAs are suitable therapeutic targets as their expression can be modulated by different available strategies. The aim of the present review is to offer clinicians a global perspective of miRNA, covering their structure and nomenclature, biogenesis, effects on gene expression, regulation of expression, and features as disease biomarkers and therapeutic targets, with special attention to ARDS. Because of the early stage of research on miRNAs applied to ARDS, attention has been focused on how knowledge sourced from basic and translational research could inspire future clinical studies. spa
dc.description.sponsorship SIN FINANCIACIÓN spa
dc.language.iso eng spa
dc.title Characteristics of microRNAs and their potential relevance for the diagnosis and therapy of the acute respiratory distress syndrome: from bench to bedside spa
dc.type article spa
dc.description.impact 4.652 JCR (2016) Q1, 4/30 Medical Laboratory Technology, 17/155 Medicine, General and Internal, 19/128 Medicine, Research and Experimental spa
dc.identifier.doi 10.1016/j.trsl.2015.11.004
dc.rights.accessRights closedAccess spa
dc.subject.uem ARN spa
dc.subject.uem Síndrome de distrés respiratorio spa
dc.subject.unesco Aparato respiratorio spa
dc.description.filiation UEM spa
dc.peerreviewed Si spa


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