Melatonin for cardioprotection in ST elevation myocardial infarction: Are we ready for the challenge?

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dc.contributor.author Domínguez Rodríguez, Alberto 
dc.contributor.author Abreu González, Pedro
dc.contributor.author Reiter, Russel J.
dc.date.accessioned 2017-01-13T15:12:59Z
dc.date.available 2017-01-13T15:12:59Z
dc.date.issued 2016
dc.identifier.citation Dominguez-Rodriguez, A., Abreu-Gonzalez, P., & Reiter, R. J. (2016). Melatonin for cardioprotection in ST elevation myocardial infarction: are we ready for the challenge?. Heart, 103 (9), 647-648. DOI: 10.1136/heartjnl-2016-310689 spa
dc.identifier.issn 13556037
dc.identifier.issn 1468201X
dc.identifier.uri http://hdl.handle.net/11268/6151
dc.description.abstract Melatonin, an endocrine product of the pineal gland, is formed predominantly during the nighttime. Light has an inhibitory effect on pineal melatonin secretion. Pineal melatonin release is synchronised by this daily light-dark cycle via a multisynaptic pathway between the eyes and the pineal gland. Light stimulates the retina to modulate the activity of the suprachiasmatic nucleus, the master biological clock.1 The suprachiasmatic nucleus controls pineal melatonin synthesis and the concentrations of melatonin in the sera of healthy subjects, which reach values of 10−10 to 10−9 mol/L during the night, with much lower concentrations being present during the day. Many publications have shown that melatonin has an important role in a variety of cardiovascular pathophysiologic processes: the indoleamine has anti-inflammatory, antioxidant, antihypertensive, antithrombotic and antilipaemic properties. spa
dc.description.sponsorship SIN FINANCIACIÓN spa
dc.language.iso eng spa
dc.subject.other Melatonin spa
dc.title Melatonin for cardioprotection in ST elevation myocardial infarction: Are we ready for the challenge? spa
dc.type article spa
dc.description.impact 6.059 JCR (2016) Q1, 17/126 Cardiac and Cardiovascular Systems spa
dc.identifier.doi 10.1136/heartjnl-2016-310689
dc.rights.accessRights closedAccess spa
dc.subject.uem Cardiología spa
dc.subject.unesco Sistema cardiovascular spa
dc.subject.unesco Tratamiento médico spa
dc.description.filiation UEC spa
dc.peerreviewed Si spa

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