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Triggers and anatomical substrates in the genesis and perpetuation of atrial fibrillation

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dc.contributor.author Sánchez-Quintana, Damián
dc.contributor.author López Mínguez, José Ramón
dc.contributor.author Pizarro, Gonzalo
dc.contributor.author Murillo Haba, Margarita
dc.contributor.author Cabrera Rodríguez, José Ángel
dc.date.accessioned 2017-02-22T19:13:41Z
dc.date.available 2017-02-22T19:13:41Z
dc.date.issued 2012
dc.identifier.citation Sánchez-Quintana, D., Ramon Lopez-Minguez, J., Pizarro, G., Murillo, M., y Angel Cabrera, J. (2012). Triggers and anatomical substrates in the genesis and perpetuation of atrial fibrillation. Current cardiology reviews, 8(4), 310-326. spa
dc.identifier.issn 1573403X
dc.identifier.uri http://hdl.handle.net/11268/6214
dc.description.abstract The definition of atrial fibrillation (AF) as a functional electrical disorder does not reflect the significant underlying structural abnormalities. Atrial and Pulmonary Vein (PV) muscle sleeve microstructural remodeling is present, and establishes a vulnerable substrate for AF maintenance. In spite of an incomplete understanding of the anatomo-functional basis for AF, current evidence demonstrates that this arrhythmia usually requires a trigger for initiation and a vulnerable electrophysiological and/or anatomical substrate for maintenance. It is still unclear whether the trigger mechanisms include focal enhanced automaticity, triggered activity and/or micro re-entry from myocardial tissue. Initiation of AF can be favored by both parasympathetic and sympathetic stimulation, which also seem to play a role in maintaining AF. Finally, evolving clinical evidence demonstrates that inflammation is associated with new-onset and recurrent AF through a mechanism that possibly involves cellular degeneration, apoptosis, and subsequent atrial fibrosis. © 2012 Bentham Science Publishers. spa
dc.description.sponsorship SIN FINANCIACIÓN spa
dc.language.iso eng spa
dc.title Triggers and anatomical substrates in the genesis and perpetuation of atrial fibrillation spa
dc.type article spa
dc.description.impact 0.546 SJR (2012) Q2, 2321/6630 Medicine, 139/332 Cardiology and cardiovascular medicine spa
dc.identifier.doi 10.2174/157340312803760721
dc.rights.accessRights closedAccess spa
dc.subject.uem Cardiología spa
dc.subject.uem Vasos sanguíneos spa
dc.subject.uem Aparato respiratorio spa
dc.subject.unesco Sistema cardiovascular spa
dc.subject.unesco Aparato respiratorio spa
dc.description.filiation UEM spa
dc.peerreviewed Si spa


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