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Effects of endotoxin lipopolysaccharide administration on the somatotropic axis 

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dc.contributor.author Soto, Luis J.
dc.contributor.author Martín Velasco, Ana Isabel
dc.contributor.author Millán, Salvador
dc.contributor.author Vara, Elena
dc.contributor.author López-Calderón, Asunción
dc.date.accessioned 2017-03-03T17:53:44Z
dc.date.available 2017-03-03T17:53:44Z
dc.date.issued 1998
dc.identifier.citation Soto, L., Martin, A. I., Millán, S., Vara, E., & López-Calderón, A. (1998). Effects of endotoxin lipopolysaccharide administration on the somatotropic axis. Journal of Endocrinology, 159(2), 239-246. spa
dc.identifier.issn 00220795
dc.identifier.uri http://hdl.handle.net/11268/6231
dc.description.abstract The aim of this work was to study the effect of chronic activation of the immune system on the somatotropic axis. Accordingly, the changes in growth hormone (GH) secretion, circulating insulin-like growth factor-I (IGF- I) and IGF binding proteins (IGFBPs) in response to endotoxin lipopolysaccharide (LPS) administration were examined in adult male Wistar rats. Acute LPS injection (2.5, 25 or 250 μg/kg) increased serum corticosterone in a dose-dependent manner and decreased serum levels of insulin and IGF-I, serum GH concentration declined linearly as the LPS dose increased. Western ligand blot showed an increase in the 33 kDa band (corresponding to IGFBP-1 and IGFBP-2) in the rats that received the highest dose of LPS (250 μg/kg). Chronic LPS administration (250 μg/kg daily for 8 days) significantly decreased body weight, serum levels of IGF-I and pituitary GH content, whereas it increased circulating IGFBP-3 (47 kDa band), IGFBP-1 and IGFBP-2 (33 kDa band) and the 24 kDa band (which possibly corresponds to IGFBP-4). Serum concentration of corticosterone and hypothalamic somatostatin content were also increased by chronic LPS treatment. These data suggest that the decrease in GH and IGF-I secretion and the increase in circulating IGFBPs are important mechanisms in body weight loss during chronic inflammation. spa
dc.description.sponsorship Sin financiación spa
dc.language.iso eng spa
dc.title Effects of endotoxin lipopolysaccharide administration on the somatotropic axis  spa
dc.type article spa
dc.description.impact 2.395 JCR (1998) Q2 23/83 Endocrinology & Metabolism spa
dc.identifier.doi 10.1677/joe.0.1590239 spa
dc.rights.accessRights closedAccess spa
dc.subject.uem Endocrinología spa
dc.subject.uem Somatotropina spa
dc.subject.uem Corticosteroides spa
dc.subject.unesco Endocrinología spa
dc.subject.unesco Hormona spa
dc.description.filiation UEM spa
dc.peerreviewed Si spa


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