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GABA (B) receptor gene expression in monkey thalamus

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dc.contributor.author Múñoz, Alberto Eduardo
dc.contributor.author Huntsman, Molly Maureen
dc.contributor.author Jones, Edward G.
dc.date.accessioned 2017-03-07T16:47:37Z
dc.date.available 2017-03-07T16:47:37Z
dc.date.issued 1998
dc.identifier.citation Muñoz, A., Huntsman, M. M., & Jones, E. G. (1998). GABAB receptor gene expression in monkey thalamus. Journal of Comparative Neurology, 394(1), 118-126. spa
dc.identifier.issn 00219967
dc.identifier.uri http://hdl.handle.net/11268/6236
dc.description.abstract Expression of g-amino butyric acid type B (GABAB) receptor gene transcripts wasexamined in the macaque monkey thalamus by in situ hybridization, using monkey-specificcRNA probes. GABABtranscript expression was widespread and of much higher density in thedorsal thalamus than in the reticular nucleus and other parts of the ventral thalamus and washighest in the epithalamus. In the dorsal thalamus, highest mRNA levels were found in theanteroventral nucleus and in the parafascicular nucleus. Sensory relay nuclei showedmoderate GABABmRNA levels. Neurons of all sizes were labeled, suggesting expression inrelay cells and interneurons, and there was no labeling of neuroglial cells. Following 10-dayperiods of monocular deprivation, levels of GABABmRNA were decreased in the deprivedmagno- and parvo-cellular laminae of the dorsal lateral geniculate nuclei, indicatingactivity-dependent regulation. High levels of GABABreceptors in the dorsal thalamus arelikely to reflect the high density of synaptic inputs from the reticular nucleus while lowexpression in the reticular nucleus implies weak, GABAB-mediated intrareticular inhibition. spa
dc.description.sponsorship SIN FINANCIACIÓN spa
dc.language.iso eng spa
dc.subject.other Zoología spa
dc.title GABA (B) receptor gene expression in monkey thalamus spa
dc.type article spa
dc.description.impact 3.476 JCR (1998) Q1, 35/202 Neurosciences; 1/117 Zoology spa
dc.rights.accessRights closedAccess spa
dc.subject.uem Neurociencia spa
dc.subject.uem Fisiología spa
dc.subject.unesco Neurología spa
dc.subject.unesco Fisiología spa
dc.description.filiation UEM spa
dc.peerreviewed Si spa


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