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Cardiovascular outcome trials in patients with chronic kidney disease: challenges associated with selection of patients and endpoints

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dc.contributor.author Rossignol, Patrick
dc.contributor.author Agarwal, R.
dc.contributor.author Canaud, B.
dc.contributor.author Charney, A.
dc.contributor.author Chatellier, Gilles
dc.contributor.author Craig, J. C.
dc.contributor.author Cushman, W. C.
dc.contributor.author Gansevoort, R. T.
dc.contributor.author Fellström, B.
dc.contributor.author Garza, D.
dc.contributor.author Guzmán, N.
dc.contributor.author Holtkamp, F. A.
dc.contributor.author London, G. M.
dc.contributor.author Massy, Z. A.
dc.contributor.author Mebazaa, A.
dc.contributor.author Mol, P. G.
dc.contributor.author Pfeffer, M. A.
dc.contributor.author Rosenberg, Y.
dc.contributor.author Ruilope Urioste, Luis Miguel
dc.contributor.author Seltzer, J.
dc.contributor.author Shah, A. M.
dc.contributor.author Shah, S.
dc.contributor.author Singh, B.
dc.contributor.author Stefánsson, B. V.
dc.contributor.author Stockbridge, N.
dc.contributor.author Stough, W. G.
dc.contributor.author Thygesen, K.
dc.contributor.author Walsh, M.
dc.contributor.author Wanner, C.
dc.contributor.author Warnock, D. G.
dc.contributor.author Wilcox, C. S.
dc.contributor.author Wittes, J.
dc.contributor.author Pitt, B.
dc.contributor.author Thompson, A.
dc.contributor.author Zannad, F.
dc.date.accessioned 2017-06-12T10:13:01Z
dc.date.available 2017-06-12T10:13:01Z
dc.date.issued 2019
dc.identifier.citation Rossignol, P., Agarwal, R., Canaud, B., Charney, A., Chatellier, G., Craig, J. C., ... & Guzmán, N. (2019). Cardiovascular outcome trials in patients with chronic kidney disease: challenges associated with selection of patients and endpoints. European Heart Journal, 40(11), 880-886. https://doi.org/10.1093/eurheartj/ehx209 spa
dc.identifier.issn 0195668X
dc.identifier.uri http://hdl.handle.net/11268/6471
dc.description.abstract Although cardiovascular disease is a major health burden for patients with chronic kidney disease, most cardiovascular outcome trials have excluded patients with advanced chronic kidney disease. Moreover, the major cardiovascular outcome trials that have been conducted in patients with end-stage renal disease have not demonstrated a treatment benefit. Thus, clinicians have limited evidence to guide the management of cardiovascular disease in patients with chronic kidney disease, particularly those on dialysis. Several factors contribute to both the paucity of trials and the apparent lack of observed treatment effect in completed studies. Challenges associated with conducting trials in this population include patient heterogeneity, complexity of renal pathophysiology and its interaction with cardiovascular disease, and competing risks for death. The Investigator Network Initiative Cardiovascular and Renal Clinical Trialists (INI-CRCT), an international organization of academic cardiovascular and renal clinical trialists, held a meeting of regulators and experts in nephrology, cardiology, and clinical trial methodology. The group identified several research priorities, summarized in this paper, that should be pursued to advance the field towards achieving improved cardiovascular outcomes for these patients. Cardiovascular and renal clinical trialists must partner to address the uncertainties in the field through collaborative research and design clinical trials that reflect the specific needs of the chronic and end-stage kidney disease populations, with the shared goal of generating robust evidence to guide the management of cardiovascular disease in patients with kidney disease. spa
dc.description.sponsorship SIN FINANCIACIÓN spa
dc.language.iso eng spa
dc.title Cardiovascular outcome trials in patients with chronic kidney disease: challenges associated with selection of patients and endpoints spa
dc.type article spa
dc.description.impact 23.425 JCR (2017) Q1, 1/128 Cardiac and Cardiovascular Systems spa
dc.identifier.doi 10.1093/eurheartj/ehx209
dc.rights.accessRights closedAccess spa
dc.subject.uem Cardiopatía coronaria spa
dc.subject.uem Riñones - Enfermedades spa
dc.subject.unesco Enfermedad cardiovascular spa
dc.description.filiation UEM spa
dc.peerreviewed Si spa


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