ACTN3 genotype influences exercise-induced muscle damage during a marathon competition

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dc.contributor.author Coso, Juan del
dc.contributor.author Valero, Marjorie
dc.contributor.author Salinero, Juan José
dc.contributor.author Lara, Beatriz
dc.contributor.author Díaz Ureña, Germán
dc.contributor.author Gallo Salazar, Cesar
dc.contributor.author Ruiz Vicente, Diana
dc.contributor.author Areces, Francisco
dc.date.accessioned 2017-10-02T11:39:19Z
dc.date.available 2017-10-02T11:39:19Z
dc.date.issued 2017
dc.identifier.citation Del Coso, J., Valero, M., Salinero, J. J., Lara, B., Díaz, G., Gallo-Salazar, C., ... & Cacabelos, R. (2017). ACTN3 genotype influences exercise-induced muscle damage during a marathon competition. European journal of applied physiology, 117(3), 409-416. DOI: 10.1007/s00421-017-3542-z spa
dc.identifier.issn 14396319
dc.identifier.issn 14396327
dc.identifier.uri http://hdl.handle.net/11268/6593
dc.description.abstract Exercise-induced muscle damage has been identified as one of the main causes of the progressive decrease in running and muscular performance in marathoners. The aim of this investigation was to determine the influence of the ACTN3 genotype on exercise-induced muscle damage produced during a marathon. Seventy-one experienced runners competed in a marathon race. Before and after the race, a sample of venous blood was obtained and maximal voluntary leg muscle power was measured during a countermovement jump. In the blood samples, the ACTN3 genotype (R577X) and the changes in serum creatine kinase and myoglobin concentrations were measured. Data from RX heterozygotes and XX mutant homozygotes were grouped as X allele carriers and compared to RR homozygotes. At the end of the race, X allele carriers presented higher serum myoglobin (774 ± 852 vs 487 ± 367 U L−1; P = 0.02) and creatine kinase concentrations (508 ± 346 vs 359 ± 170 ng mL−1; P = 0.04) than RR homozygotes. Pre-to-post-race maximal voluntary leg muscle power reduction was more pronounced in X allele carriers than RR homozygotes (−34.4 ± 16.1 vs −27.3 ± 15.4%; P = 0.05). X allele carriers self-reported higher levels of lower limb muscle pain (7 ± 2 vs 6 ± 2 cm; P = 0.02) than RR homozygotes at the end of the race. In comparison to RR homozygotes, X allele carriers for the R577X polymorphism of the ACTN3 gene presented higher values for typical markers of exercise-induced muscle damage during a competitive marathon. Thus, the absence of a functional α-actinin-3 produced by the X allele might induce higher levels of muscle breakdown during prolonged running events. spa
dc.description.sponsorship Universidad Camilo José Cela (Proyecto DAMUS) spa
dc.language.iso eng spa
dc.title ACTN3 genotype influences exercise-induced muscle damage during a marathon competition spa
dc.type article spa
dc.description.impact 2.401 JCR (2017) Q2, 27/81 Sport sciences; Q3, 45/83 Physiology spa
dc.identifier.doi 10.1007/s00421-017-3542-z
dc.rights.accessRights closedAccess spa
dc.subject.uem Músculos - Enfermedades spa
dc.subject.uem Ejercicios isométricos spa
dc.subject.unesco Efectos fisiológicos spa
dc.subject.unesco Deporte spa
dc.description.filiation UEM spa
dc.peerreviewed Si spa

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