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Serum levels of RANKL and OPG, and the RANKL/OPG ratio in bisphosphonate-related osteonecrosis of the jaw: Are they useful biomarkers for the advanced stages of osteonecrosis?

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dc.contributor.author Bagán Debón, Leticia María
dc.contributor.author Jiménez, Yolanda
dc.contributor.author Rubert Aparici, Andrea
dc.contributor.author Leopoldo Rodado, Manuel
dc.contributor.author Bagán Sebastián, José Vicente
dc.date.accessioned 2017-10-11T08:18:53Z
dc.date.available 2017-10-11T08:18:53Z
dc.date.issued 2017
dc.identifier.citation Bagán, L., Jiménez, Y., Leopoldo, M., Rubert, A., & Bagán, J. (2017). Serum levels of RANKL and OPG, and the RANKL/OPG ratio in bisphosphonate-related osteonecrosis of the jaw: Are they useful biomarkers for the advanced stages of osteonecrosis?. Medicina oral, patologia oral y cirugia bucal, 22(5), e542-e547. DOI: 10.4317/medoral.22128 spa
dc.identifier.issn 16986946
dc.identifier.uri http://hdl.handle.net/11268/6621
dc.description.abstract We determined whether serum levels of Receptor Activator for Nuclear Factor κ B Ligand (RANKL), Osteoprotegerin (OPG), and the RANKL/OPG ratio could be useful biomarkers for the severity of oral lesions in bisphosphonate-related osteonecrosis of the jaw (BRONJ). A case-control study in which Group 1 consisted of 41 patients with BRONJ due to bisphosphonates, and Group 2 consisted of 44 healthy control cases. The plasma levels of RANKL and OPG were analyzed by an ELISA assay. The OPG/RANKL ratio was also calculated. We determined if the mean serum values differed among the different stages of BRONJ. Serum levels of RANKL were lower in Group 1 than in Group 2 (p =0.01), and serum levels of OPG were higher in patients with BRONJ than in the controls (p =0.006). The ratio of RANKL/OPG was greater in the controls than in Group 1 (p >0.01). There were no significant differences in the serum levels of RANKL and OPG among the different stages of osteonecrosis (p >0.05). Serum levels of RANKL and OPG, and the RANKL/OPG ratio were not valuable biomarkers for determining the severity of oral lesions in patients with BRONJ. spa
dc.description.sponsorship SIN FINANCIACION spa
dc.language.iso spa spa
dc.title Serum levels of RANKL and OPG, and the RANKL/OPG ratio in bisphosphonate-related osteonecrosis of the jaw: Are they useful biomarkers for the advanced stages of osteonecrosis? spa
dc.type article spa
dc.description.impact 1.671 JCR (2017) Q2, 41/91 Dentistry, Oral Surgery and Medicine spa
dc.identifier.doi 10.4317/medoral.22128
dc.rights.accessRights openAccess spa
dc.subject.uem Necrosis spa
dc.subject.uem Odontología spa
dc.subject.unesco Odontología spa
dc.description.filiation UEV spa
dc.relation.publisherversion http://www.medicinaoral.com/pubmed/medoralv22_i5_p542 .pdf spa
dc.peerreviewed Si spa


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