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Effect of Serum Growth Differentiation Factor-15 and the Syntax Score on 2-Year Outcomes in Patients With Acute Coronary Syndrome

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dc.contributor.author Domínguez Rodríguez, Alberto 
dc.contributor.author Abreu González, Pedro
dc.contributor.author Avanzas, Pablo
dc.contributor.author Consuegra Sánchez, Luciano
dc.date.accessioned 2017-11-30T17:08:38Z
dc.date.available 2017-11-30T17:08:38Z
dc.date.issued 2016
dc.identifier.citation Dominguez-Rodriguez, A., Abreu-Gonzalez, P., Avanzas, P., & Consuegra-Sanchez, L. (2016). Effect of serum Growth Differentiation Factor-15 and the Syntax score on 2-year outcomes in patients with acute coronary syndrome. The American Journal of Cardiology, 117(10), 1569-1574. spa
dc.identifier.issn 0002-9149
dc.identifier.uri http://hdl.handle.net/11268/6812
dc.description.abstract Growth differentiation factor-15 (GDF-15) is produced by cardiomyocytes and atherosclerotic lesions under stress conditions, but little is known about its relation with severity and complexity of coronary lesions. The aim of this study was to investigate the association between GDF-15 and the syntax score for risk prediction of major adverse cardiovascular events (MACE) at 2-year follow-up in patients with non-ST-segment elevation acute coronary syndrome (NSTEACS). This is a prospective cohort study of 502 patients with NSTEACS. The syntax score was calculated from baseline coronary angiography. Blood samples were obtained at study entry for the assessment of GDF-15 and high-sensitivity C reactive protein. One hundred and three patients (20.5%) showed MACE at 2-year follow-up. Patients who developed MACE had greater GDF-15 concentrations and syntax score (p <0.001) compared to patients who did not. There was a positive, but moderate, correlation between GDF-15 and syntax score (ρ = 0.45, p <0.0001). On Cox regression analysis, only GDF-15 levels (p <0.001), body mass index (p = 0.04), and syntax score (p <0.001) remained independent predictors of the MACE. The area under the curve of GDF-15 (0.912, 95% confidence interval 0.894 to 0.944) was significantly greater compared to high-sensitivity C reactive protein and syntax score. In conclusion, in patients with NSTEACS, levels of GDF-15 at admission were correlated with the syntax score and independently associated with an increased risk of MACE during 2-year follow-up. spa
dc.description.sponsorship SIN FINANCIACIÓN spa
dc.language.iso eng spa
dc.title Effect of Serum Growth Differentiation Factor-15 and the Syntax Score on 2-Year Outcomes in Patients With Acute Coronary Syndrome spa
dc.type article spa
dc.description.impact 3.398 JCR (2016) Q2, 47/126 Cardiac & Cardiovascular Systems spa
dc.identifier.doi 10.1016/j.amjcard.2016.02.031
dc.rights.accessRights closedAccess spa
dc.subject.uem Cardiología spa
dc.subject.unesco Enfermedad cardiovascular spa
dc.description.filiation UEC spa
dc.peerreviewed Si spa


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