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Thrombus Aspirated from Patients with ST-Elevation Myocardial Infarction: Association between 3-Nitrotyrosine and Inflammatory Markers - Insights from ARTERIA Study

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dc.contributor.author Domínguez Rodríguez, Alberto 
dc.contributor.author Abreu González, Pedro
dc.contributor.author Consuegra Sánchez, Luciano
dc.contributor.author Avanzas, Pablo
dc.contributor.author Sánchez Grande, Alejandro
dc.contributor.author Conesa Zamora, Pablo
dc.date.accessioned 2017-12-07T10:52:02Z
dc.date.available 2017-12-07T10:52:02Z
dc.date.issued 2016
dc.identifier.citation Dominguez-Rodriguez, A., Abreu-Gonzalez, P., Consuegra-Sanchez, L., Avanzas, P., Sanchez-Grande, A., & Conesa-Zamora, P. (2016). Thrombus Aspirated from Patients with ST-Elevation Myocardial Infarction: Association between 3-Nitrotyrosine and Inflammatory Markers-Insights from ARTERIA Study. International Journal of Medical Sciences, 13(7), 477-482. DOI: 10.7150/ijms.15463 spa
dc.identifier.issn 1449-1907
dc.identifier.uri http://hdl.handle.net/11268/6830
dc.description.abstract Recent studies have demonstrated that inflammatory cells are a component that plays a role in thrombus formation in ST-elevation myocardial infarction (STEMI). 3-nitrotyrosine (3-NO2-Tyr), a specific marker for protein modification by nitric oxide-derived oxidants, is increased in human atherosclerotic lesions. The purpose of this study was to determine the possible association of inflammatory markers of coronary thrombi with nitroxidative stress. Intracoronary thrombus (n= 51) and blood from the systemic circulation were obtained by thromboaspiration in 138 consecutive STEMI patients presenting for primary percutaneous coronary intervention (PCI). Each blood and intracoronary thrombus were measured simultaneously the following biomarkers: C-reactive protein (CRP), 3-NO2-Tyr, soluble CD 40 ligand (sCD40L), vascular cellular adhesion molecule-1 (VCAM- 1) and haemoglobin content (only in coronary thrombus). Time delay in minutes from symptom onset to PCI was 244 +/- 324. Serum CRP was positively correlated to CRP content in the thrombus (r= 0.395; p = 0.02) and serum sCD40L was negatively correlated to sCD40L in the thrombus (r= -0.394; p = 0.02). Patients were divided into tertiles according to thrombi 3-NO2-Tyr concentration: 1st tertile (<0.146ng/mg), 2nd tertile (0.146-0.485ng/mg) and 3rd tertile (> 0.485ng/mg). Thus, thrombus in the highest tertile had significantly higher levels of CRP (p= 0.002), VCAM- 1 (p= 0.003) and haemoglobin (p= 0.002). In conclusion, the present study demonstrated that coronary thrombi with higher levels of 3-NO2-Tyr content often contain more inflammatory markers which could have a direct impact on the efficacy of drugs or devices used for coronary reperfusion. spa
dc.description.sponsorship Spanish Society of Cardiology for Clinical Research in Cardiology 2014 spa
dc.language.iso eng spa
dc.title Thrombus Aspirated from Patients with ST-Elevation Myocardial Infarction: Association between 3-Nitrotyrosine and Inflammatory Markers - Insights from ARTERIA Study spa
dc.type article spa
dc.description.impact 2.399 JCR (2016) Q1, 36/155 Medicine, general & Internal spa
dc.identifier.doi 10.7150/ijms.15463
dc.rights.accessRights openAccess spa
dc.subject.uem Cardiología spa
dc.subject.uem Trombosis spa
dc.subject.unesco Enfermedad cardiovascular spa
dc.description.filiation UEC spa
dc.peerreviewed Si spa


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